TMEM127 Antibody (PACO60845)
- SKU:
- PACO60845
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Applications:
- IHC
- Applications:
- IF
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | TMEM127 Antibody (PACO60845) |
| Antibody SKU: | PACO60845 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, IHC, IF |
| Recommended Dilutions: | ELISA:1:2000-1:10000, IHC:1:200-1:500, IF:1:50-1:200 |
| Species Reactivity: | Human |
| Immunogen: | Recombinant Human Transmembrane protein 127 protein (1-95AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
| Purification Method: | >95%, Protein G purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | IHC image of PACO60845 diluted at 1:400 and staining in paraffin-embedded human heart tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system. |
 | Immunofluorescence staining of A549 cells with PACO60845 at 1:133, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L). |
| Background: | Controls cell proliferation acting as a negative regulator of TOR signaling pathway mediated by mTORC1. May act as a tumor suppressor. |
| Synonyms: | Transmembrane protein 127, TMEM127 |
| UniProt Protein Function: | Controls cell proliferation acting as a negative regulator of TOR signaling pathway mediated by mTORC1. May act as a tumor suppressor. |
| UniProt Protein Details: | |
| NCBI Summary: | This gene encodes a transmembrane protein with 3 predicted transmembrane domains. The protein is associated with a subpopulation of vesicular organelles corresponding to early endosomal structures, with the Golgi, and with lysosomes, and may participate in protein trafficking between these structures. Mutations in this gene and several other genes cause pheochromocytomas. Alternatively spliced transcript variants encoding the same protein have been identified. [provided by RefSeq, Aug 2010] |
| UniProt Code: | O75204 |
| NCBI GenInfo Identifier: | 300934846 |
| NCBI Gene ID: | 55654 |
| NCBI Accession: | NP_001180233.1 |
| UniProt Secondary Accession: | O75204,D3DXH0 |
| UniProt Related Accession: | O75204 |
| Molecular Weight: | 25,842 Da |
| NCBI Full Name: | transmembrane protein 127 |
| NCBI Synonym Full Names: | transmembrane protein 127 |
| NCBI Official Symbol: | TMEM127 |
| NCBI Official Synonym Symbols: | |
| NCBI Protein Information: | transmembrane protein 127 |
| UniProt Protein Name: | Transmembrane protein 127 |
| UniProt Synonym Protein Names: | |
| Protein Family: | Transmembrane protein |
| UniProt Gene Name: | TMEM127 |
| UniProt Entry Name: |
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