TMEM123 Antibody (PACO16883)
- SKU:
- PACO16883
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Applications:
- IHC
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | TMEM123 Antibody (PACO16883) |
| Antibody SKU: | PACO16883 |
| Size: | 50ul |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, IHC |
| Recommended Dilutions: | ELISA:1:2000-1:10000, IHC:1:30-1:150 |
| Species Reactivity: | Human |
| Immunogen: | Fusion protein of human TMEM123 |
| Form: | Liquid |
| Storage Buffer: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
| Purification Method: | Antigen affinity purification |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using PACO16883(TMEM123 Antibody) at dilution 1/25, on the right is treated with fusion protein. (Original magnification: x200). |
| Background: | This gene encodes a highly glycosylated transmembrane protein with a high content of threonine and serine residues in its extracellular domain, similar to a broadly defined category of proteins termed mucins. Exposure of some cell types to anti-PORIMIN (pro-oncosis receptor inducing membrane injury) antibody, crosslinks this protein on the cell surface and induces a type of cell death termed oncosis. Oncosis is distinct from apoptosis and is characterized by a loss of cell membrane integrity without DNA fragmentation. This gene product is proposed to function as a cell surface receptor that mediates cell death. |
| Synonyms: | transmembrane protein 123 |
| UniProt Protein Function: | Implicated in oncotic cell death, characterized by cell swelling, organelle swelling, vacuolization and increased membrane permeability. |
| UniProt Protein Details: | |
| NCBI Summary: | This gene encodes a highly glycosylated transmembrane protein with a high content of threonine and serine residues in its extracellular domain, similar to a broadly defined category of proteins termed mucins. Exposure of some cell types to anti-PORIMIN (pro-oncosis receptor inducing membrane injury) antibody, crosslinks this protein on the cell surface and induces a type of cell death termed oncosis. Oncosis is distinct from apoptosis and is characterized by a loss of cell membrane integrity without DNA fragmentation. This gene product is proposed to function as a cell surface receptor that mediates cell death. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q8N131 |
| NCBI GenInfo Identifier: | 100913218 |
| NCBI Gene ID: | 114908 |
| NCBI Accession: | NP_443164.2 |
| UniProt Secondary Accession: | Q8N131,Q8IWS2, Q96QV2 |
| UniProt Related Accession: | Q8N131 |
| Molecular Weight: | 22 |
| NCBI Full Name: | porimin |
| NCBI Synonym Full Names: | transmembrane protein 123 |
| NCBI Official Symbol: | TMEM123 |
| NCBI Official Synonym Symbols: | KCT3; PORMIN; PORIMIN |
| NCBI Protein Information: | porimin |
| UniProt Protein Name: | Porimin |
| UniProt Synonym Protein Names: | Keratinocytes-associated transmembrane protein 3; KCT-3; Pro-oncosis receptor inducing membrane injury; Transmembrane protein 123 |
| Protein Family: | Porimin |
| UniProt Gene Name: | TMEM123 |
| UniProt Entry Name: |
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