Tlr7 Antibody (PACO30430)
- SKU:
- PACO30430
- Product Type:
- Antibody
- Reactivity:
- Mouse
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Applications:
- WB
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | Tlr7 Antibody (PACO30430) |
| Antibody SKU: | PACO30430 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB |
| Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:500-1:2000 |
| Species Reactivity: | Mouse, Human |
| Immunogen: | Recombinant Mouse Toll-like receptor 7 protein (27-348AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
| Purification Method: | >95%, Protein G purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Western Blot Positive WB detected in: Jurkat whole cell lysate, K562 whole cell lysate, A549 whole cell lysate All lanes: Tlr7 antibody at 2µg/ml Secondary Goat polyclonal to rabbit IgG at 1/50000 dilution Predicted band size: 122 kDa Observed band size: 122 kDa . |
| Background: | Key component of innate and adaptive immunity. TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. TLR7 is a nucleotide-sensing TLR which is activated by single-stranded RNA. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response |
| Synonyms: | Toll-like receptor 7, Tlr7 |
| UniProt Protein Function: | TLR7: Key component of innate and adaptive immunity. TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. TLR7 is a nucleotide-sensing TLR which is activated by single-stranded RNA. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Interacts with MYD88 via their respective TIR domains. Interacts with UNC93B1. Detected in brain, placenta, spleen, stomach, small intestine, lung and in plasmacytoid pre-dendritic cells. Belongs to the Toll-like receptor family. |
| UniProt Protein Details: | Protein type:Membrane protein, integral Cellular Component: cytoplasm; cytoplasmic vesicle; endoplasmic reticulum; endosome; integral to membrane; lysosome; membrane; plasma membrane; receptor complex Molecular Function:double-stranded RNA binding; drug binding; protein binding; single-stranded RNA binding; siRNA binding; transmembrane receptor activity Biological Process: defense response to virus; I-kappaB phosphorylation; immune response; immune system process; inflammatory response; innate immune response; microglial cell activation; MyD88-dependent toll-like receptor signaling pathway; positive regulation of chemokine production; positive regulation of interferon-alpha biosynthetic process; positive regulation of interferon-beta biosynthetic process; positive regulation of interferon-gamma biosynthetic process; positive regulation of interleukin-6 production; positive regulation of interleukin-8 biosynthetic process; positive regulation of interleukin-8 production; positive regulation of NF-kappaB import into nucleus; regulation of protein amino acid phosphorylation; signal transduction; toll-like receptor 7 signaling pathway; toll-like receptor signaling pathway |
| UniProt Code: | P58681 |
| NCBI GenInfo Identifier: | 595582289 |
| NCBI Gene ID: | 170743 |
| NCBI Accession: | NP_001277684.1 |
| UniProt Secondary Accession: | P58681,Q923I1, |
| UniProt Related Accession: | P58681 |
| Molecular Weight: | 40.8 kDa |
| NCBI Full Name: | toll-like receptor 7 isoform a |
| NCBI Synonym Full Names: | toll-like receptor 7 |
| NCBI Official Symbol: | Tlr7 |
| NCBI Protein Information: | toll-like receptor 7 |
| UniProt Protein Name: | Toll-like receptor 7 |
| Protein Family: | Toll-like receptor |
| UniProt Gene Name: | Tlr7 |
| UniProt Entry Name: | TLR7_MOUSE |
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