Antibody Name:	Tlr7 Antibody (PACO30430)
Antibody SKU:	PACO30430
Size:	50ug
Host Species:	Rabbit
Tested Applications:	ELISA, WB
Recommended Dilutions:	ELISA:1:2000-1:10000, WB:1:500-1:2000
Species Reactivity:	Mouse, Human
Immunogen:	Recombinant Mouse Toll-like receptor 7 protein (27-348AA)

Form:	Liquid
Storage Buffer:	Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Purification Method:	>95%, Protein G purified
Clonality:	Polyclonal
Isotype:	IgG
Conjugate:	Non-conjugated

Western Blot
Positive WB detected in: Jurkat whole cell lysate, K562 whole cell lysate, A549 whole cell lysate
All lanes: Tlr7 antibody at 2µg/ml
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 122 kDa
Observed band size: 122 kDa
.

Background:	Key component of innate and adaptive immunity. TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. TLR7 is a nucleotide-sensing TLR which is activated by single-stranded RNA. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response
Synonyms:	Toll-like receptor 7, Tlr7

UniProt Protein Function:	TLR7: Key component of innate and adaptive immunity. TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. TLR7 is a nucleotide-sensing TLR which is activated by single-stranded RNA. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Interacts with MYD88 via their respective TIR domains. Interacts with UNC93B1. Detected in brain, placenta, spleen, stomach, small intestine, lung and in plasmacytoid pre-dendritic cells. Belongs to the Toll-like receptor family.
UniProt Protein Details:	Protein type:Membrane protein, integral Cellular Component: cytoplasm; cytoplasmic vesicle; endoplasmic reticulum; endosome; integral to membrane; lysosome; membrane; plasma membrane; receptor complex Molecular Function:double-stranded RNA binding; drug binding; protein binding; single-stranded RNA binding; siRNA binding; transmembrane receptor activity Biological Process: defense response to virus; I-kappaB phosphorylation; immune response; immune system process; inflammatory response; innate immune response; microglial cell activation; MyD88-dependent toll-like receptor signaling pathway; positive regulation of chemokine production; positive regulation of interferon-alpha biosynthetic process; positive regulation of interferon-beta biosynthetic process; positive regulation of interferon-gamma biosynthetic process; positive regulation of interleukin-6 production; positive regulation of interleukin-8 biosynthetic process; positive regulation of interleukin-8 production; positive regulation of NF-kappaB import into nucleus; regulation of protein amino acid phosphorylation; signal transduction; toll-like receptor 7 signaling pathway; toll-like receptor signaling pathway
UniProt Code:	P58681
NCBI GenInfo Identifier:	595582289
NCBI Gene ID:	170743
NCBI Accession:	NP_001277684.1
UniProt Secondary Accession:	P58681,Q923I1,
UniProt Related Accession:	P58681
Molecular Weight:	40.8 kDa
NCBI Full Name:	toll-like receptor 7 isoform a
NCBI Synonym Full Names:	toll-like receptor 7
NCBI Official Symbol:	Tlr7
NCBI Protein Information:	toll-like receptor 7
UniProt Protein Name:	Toll-like receptor 7
Protein Family:	Toll-like receptor
UniProt Gene Name:	Tlr7
UniProt Entry Name:	TLR7_MOUSE