Description
| Product Name: | TLK1 Polyclonal Antibody |
| Product Code: | CAB21987 |
| Reactivity: | Human, Mouse, Rat |
| Applications: | Western blotting |
| Host Species: | Rabbit |
| Purification Method: | Affinity purification |
| Isotype: | IgG |
| Reactivity: | Human, Mouse, Rat |
| Tested Applications: | WB, ELISA |
| Key Applications: | Western blotting |
| Recommended Dilution: | WB 1:500-1:1000 |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300, 50% glycerol, pH7.3. |
| Positive Samples: | HeLa, Jurkat, NIH/3T3 |
| Cellular Location: | Nucleus |
The protein encoded by this gene is a serine/threonine kinase that may be involved in the regulation of chromatin assembly. The encoded protein is only active when it is phosphorylated, and this phosphorylation is cell cycle-dependent, with the maximal activity of this protein coming during S phase. The catalytic activity of this protein is diminished by DNA damage and by blockage of DNA replication. Three transcript variants encoding different isoforms have been found for this gene.
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 150-250 of human TLK1 (NP_036422.3). |
| Sequence: | FEYQG GNGSS PVRGI PPAIR SPQNS HSHST PSSSV RPNSP SPTAL AFGDH PIVQP KQLSF KIIQT DLTML KLAAL ESNKI QDLEK KEGRI DDLLR ANCDL R |
| Synonyms: | PKU-beta |
| Calculated MW: | 87kDa |
| Observed MW: | 87kDa |
