TLK1 Antibody (PACO05832)
- SKU:
- PACO05832
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Applications:
- IF
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | TLK1 Antibody (PACO05832) |
| Antibody SKU: | PACO05832 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, IF |
| Recommended Dilutions: | ELISA:1:5000, IF:1:200-1:1000 |
| Species Reactivity: | Human, Mouse |
| Immunogen: | Synthesized peptide derived from human TLK1 around the non-phosphorylation site of S764. |
| Form: | Liquid |
| Storage Buffer: | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification Method: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
| Synonyms: | TLK1; KIAA0137; Serine/threonine-protein kinase tousled-like 1; PKU-β; Tousled-like kinase 1 |
| UniProt Protein Function: | TLK1 iso1: a protein kinase of the TLK family. Rapidly and transiently inhibited by phosphorylation following the generation of DNA double-stranded breaks during S-phase. This is cell cycle checkpoint and ATM-pathway dependent and appears to regulate processes involved in chromatin assembly. Isoform 3 phosphorylates and enhances the stability of the t-SNARE SNAP23, augmenting its assembly with syntaxin. Cell-cycle regulated, maximal activity in S-phase. Inactivated by phosphorylation, possibly by CHK1. Three splice variant isoforms have been described.Protein type: Protein kinase, Other; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); EC 2.7.11.1; Other group; TLK familyChromosomal Location of Human Ortholog: 2q31.1Cellular Component: nucleusMolecular Function: protein serine/threonine kinase activity; ATP bindingBiological Process: intracellular protein transport; regulation of chromatin assembly or disassembly; chromatin modification; cell cycle; response to DNA damage stimulus; protein amino acid phosphorylation |
| UniProt Protein Details: | |
| NCBI Summary: | The protein encoded by this gene is a serine/threonine kinase that may be involved in the regulation of chromatin assembly. The encoded protein is only active when it is phosphorylated, and this phosphorylation is cell cycle-dependent, with the maximal activity of this protein coming during S phase. The catalytic activity of this protein is diminished by DNA damage and by blockage of DNA replication. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011] |
| UniProt Code: | Q9Y4F6 |
| NCBI GenInfo Identifier: | 211971036 |
| NCBI Gene ID: | 9874 |
| NCBI Accession: | NP_001130026.1 |
| UniProt Secondary Accession: | Q9Y4F6,Q14150, Q8N591, Q9NYH2, Q9Y4F6, B3KR15, B4DX87 |
| UniProt Related Accession: | Q9Y4F6,Q9UKI8 |
| Molecular Weight: | 86,700 Da |
| NCBI Full Name: | serine/threonine-protein kinase tousled-like 1 isoform 2 |
| NCBI Synonym Full Names: | tousled-like kinase 1 |
| NCBI Official Symbol: | TLK1 |
| NCBI Official Synonym Symbols: | PKU-beta |
| NCBI Protein Information: | serine/threonine-protein kinase tousled-like 1; SNARE protein kinase SNAK; serine threonine protein kinase |
| UniProt Protein Name: | Serine/threonine-protein kinase tousled-like 1 |
| UniProt Synonym Protein Names: | PKU-beta; Tousled-like kinase 1 |
| Protein Family: | Serine/threonine-protein kinase tousled |
| UniProt Gene Name: | TLK1 |
| UniProt Entry Name: | TLK1_HUMAN |
Related Products
TLK1 Polyclonal Antibody (CAB21987)
OverviewProduct Name:TLK1 Polyclonal AntibodyProduct Code:CAB21987Reactivity:Human, Mouse, RatApplications:Western blotting<
TLK1 Polyclonal Antibody (CAB8913)
TLK1 Polyclonal Antibody (CAB8913)The product page for this antibody is being prepared. If you have a question please don't hesitate to get in touch!
Human TLK1/PKU-beta Recombinant Protein (RPES0925)
Cell Cycle Recombinant Proteins
system_update_altDatasheetHuman TLK1/PKU-beta Recombinant Protein The protein encoded by this gene is a serine/threonine kinase that may be involved in the regulation of chromatin assembly. The e
HS3ST3B1 Antibody
Overview Product Name:HS3ST3B1 AntibodyProduct Code:PACO64781Size:50µLTarget Names:HS3ST3B1Species Reactivity:Human<