TK Antibody (PACO22733)
- SKU:
- PACO22733
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Applications:
- WB
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | TK Antibody (PACO22733) |
| Antibody SKU: | PACO22733 |
| Size: | 100ul |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB |
| Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:500-1:3000 |
| Species Reactivity: | Human |
| Immunogen: | Synthesized peptide derived from internal of human KITH_HHV1. |
| Form: | Liquid |
| Storage Buffer: | Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Purification Method: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Western blot analysis of extracts from HeLa cells, using KITH_HHV1 antibody. |
| Background: | In latent infection, may allow the virus to be reactivated and to grow in cells lacking a high concentration of phosphorylated nucleic acid precursors, such as nerve cells that do not replicate their genome By similarity. |
| Synonyms: | Thymidine kinase; EC=2.7.1.21; TK; UL23; |
| UniProt Protein Function: | Function: In latent infection, may allow the virus to be reactivated and to grow in cells lacking a high concentration of phosphorylated nucleic acid precursors, such as nerve cells that do not replicate their genome By similarity.Catalytic activity: ATP + thymidine = ADP + thymidine 5'-phosphate.Subunit structure: Homodimer By similarity.Biotechnological use: Used in molecular biology as a selectable marker to identify transfected eukaryotic cells. Used in cancer suicide gene therapy to selectively kill transformed cells.Miscellaneous: Phosphorylates and thereby activates certain drugs used to treat herpes simplex infections like acyclovir (ACV), valaciclovir, and famciclovir to a toxic form, that leads to successful suppression of the infection, while the uninfected cell does not have this ability because it lacks TK. Mutations in thymidine kinase may induce HHV resistance to antiviral therapies in immunocompromised patients. The most frequently observed resistant strains are unable to express TK and are avirulent in animal models of disease. Resistance may be acquired less frequently by selecting variants which no longer recognize ACV or ACV triphosphate as substrates but which retain normal functions.The sequence shown is that of strain TAS.Sequence similarities: Belongs to the herpesviruses thymidine kinase family. |
| UniProt Protein Details: | |
| NCBI Summary: | |
| UniProt Code: | Q9QNF7 |
| NCBI GenInfo Identifier: | 59799779 |
| NCBI Gene ID: | 0 |
| NCBI Accession: | Q9QNF7.1 |
| UniProt Secondary Accession: | Q9QNF7,Q9ENR2, Q9ENR3, Q9ENR4, Q9ENR5, Q9ENR6, Q9ENR7 Q9ENR8, Q9ENR9, Q9ICF2 |
| UniProt Related Accession: | Q9QNF7 |
| Molecular Weight: | 40,897 Da |
| NCBI Full Name: | Thymidine kinase |
| NCBI Synonym Full Names: | |
| NCBI Official Symbol: | |
| NCBI Official Synonym Symbols: | |
| NCBI Protein Information: | |
| UniProt Protein Name: | Thymidine kinase |
| UniProt Synonym Protein Names: | |
| Protein Family: | Tk-subtilisin |
| UniProt Gene Name: | TK |
| UniProt Entry Name: | KITH_HHV1 |
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