tir Antibody (PACO50426)
- SKU:
- PACO50426
- Product Type:
- Antibody
- Reactivity:
- Bacteria - Escherichia coli
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | tir Antibody (PACO50426) |
| Antibody SKU: | PACO50426 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA |
| Recommended Dilutions: | |
| Species Reactivity: | Escherichia coli O157:H7 |
| Immunogen: | Recombinant Escherichia coli O157:H7 Translocated intimin receptor Tir protein (252-362AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
| Purification Method: | >95%, Protein G purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
| Background: | Multifunctional protein that is required for efficient pedestal formation in host epithelial cells during infection. The extracellular region acts as a receptor for bacterial intimin, allowing the bacterium to attach tightly to the host-cell surface. Simultaneously, the intracellular region initiates a signaling cascade in the host cell, which leads to actin polymerization and formation of actin pedestals at the sites of bacterial adhesion (By similarity). |
| Synonyms: | Translocated intimin receptor Tir (Secreted effector protein Tir), tir, espE |
| UniProt Protein Function: | Multifunctional protein that is required for efficient pedestal formation in host epithelial cells during infection. The extracellular region acts as a receptor for bacterial intimin, allowing the bacterium to attach tightly to the host-cell surface. Simultaneously, the intracellular region initiates a signaling cascade in the host cell, which leads to actin polymerization and formation of actin pedestals at the sites of bacterial adhesion (). |
| UniProt Protein Details: | |
| NCBI Summary: | |
| UniProt Code: | C6UYL8 |
| NCBI GenInfo Identifier: | 485657470 |
| NCBI Gene ID: | |
| NCBI Accession: | WP_001301454.1 |
| UniProt Secondary Accession: | C6UYL8 |
| UniProt Related Accession: | C6UYL8 |
| Molecular Weight: | |
| NCBI Full Name: | translocated intimin receptor Tir |
| NCBI Synonym Full Names: | |
| NCBI Official Symbol: | |
| NCBI Official Synonym Symbols: | |
| NCBI Protein Information: | |
| UniProt Protein Name: | Translocated intimin receptor Tir |
| UniProt Synonym Protein Names: | Secreted effector protein Tir |
| Protein Family: | Tir chaperone |
| UniProt Gene Name: | tir |
| UniProt Entry Name: | TIR_ECO5T |
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