TIPRL Antibody (PACO30410)
- SKU:
- PACO30410
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | TIPRL Antibody (PACO30410) |
| Antibody SKU: | PACO30410 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA |
| Recommended Dilutions: | |
| Species Reactivity: | Human |
| Immunogen: | Recombinant Human TIP41-like protein (1-178AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
| Purification Method: | >95%, Protein G purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
| Background: | May be a allosteric regulator of serine/threonine-protein phosphatase 2A (PP2A). Isoform 1 inhibits catalytic activity of the PP2A(D) core complex in vitro. The PP2A(C):TIPRL complex does not show phosphatase activity. May play a role in the regulation of ATM/ATR signaling pathway controlling DNA replication and repair. |
| Synonyms: | TIP41-like protein (Putative MAPK-activating protein PM10) (Type 2A-interacting protein) (TIP), TIPRL |
| UniProt Protein Function: | TIPRL: May be a allosteric regulator of serine/threonine- protein phosphatase 2A (PP2A). Isoform 1 inhibits catalytic activity of the PP2A(D) core complex in vitro. The PP2A(C):TIPRL complex does not show phosphatase activity. May play a role in the regulation of ATM/ATR signaling pathway controlling DNA replication and repair. Belongs to the TIP41 family. 2 isoforms of the human protein are produced by alternative splicing.Protein type: Unknown functionChromosomal Location of Human Ortholog: 1q23.2Cellular Component: cytoplasm; intracellular membrane-bound organelleMolecular Function: protein bindingBiological Process: DNA damage checkpoint; negative regulation of protein phosphatase type 2A activity |
| UniProt Protein Details: | |
| NCBI Summary: | TIPRL is an inhibitory regulator of protein phosphatase-2A (PP2A) (see PPP2CA; MIM 176915), PP4 (see PPP4C; MIM 602035), and PP6 (see PPP6C; MIM 612725) (McConnell et al., 2007 [PubMed 17384681]).[supplied by OMIM, Nov 2010] |
| UniProt Code: | O75663 |
| NCBI GenInfo Identifier: | 74739629 |
| NCBI Gene ID: | 261726 |
| NCBI Accession: | O75663.2 |
| UniProt Secondary Accession: | O75663,Q5HYB2, Q8IZ86, B2R8V3 |
| UniProt Related Accession: | O75663 |
| Molecular Weight: | 20,214 Da |
| NCBI Full Name: | TIP41-like protein |
| NCBI Synonym Full Names: | TOR signaling pathway regulator |
| NCBI Official Symbol: | TIPRL |
| NCBI Official Synonym Symbols: | TIP; TIP41; TIPRL1 |
| NCBI Protein Information: | TIP41-like protein |
| UniProt Protein Name: | TIP41-like protein |
| UniProt Synonym Protein Names: | Putative MAPK-activating protein PM10; Type 2A-interacting protein; TIP |
| Protein Family: | TIP41-like protein |
| UniProt Gene Name: | TIPRL |
| UniProt Entry Name: | TIPRL_HUMAN |
Related Products
SIM1 Antibody
Overview Product Name:SIM1 AntibodyProduct Code:PACO64949Size:50µLTarget Names:SIM1Species Reactivity:HumanHost
eutC Antibody
Overview Product Name:eutC AntibodyProduct Code:PACO64709Size:50µLTarget Names:eutCSpecies Reactivity:Escherichia coli
EPHA10 Antibody
Overview Product Name:EPHA10 AntibodyProduct Code:PACO64693Size:50µLTarget Names:EPHA10Species Reactivity:HumanH
otsB Antibody
Overview Product Name:otsB AntibodyProduct Code:PACO64885Size:50µLTarget Names:otsBSpecies Reactivity:Escherichia coli
PCDHA8 Antibody
Overview Product Name:PCDHA8 AntibodyProduct Code:PACO64893Size:50µLTarget Names:PCDHA8Species Reactivity:HumanH