Thyroid Hormone Receptor alpha Transcription Factor Activity Assay
- SKU:
- TFAB00173
- Product Type:
- ELISA Kit
- ELISA Type:
- Transcription Factor Assay
- Analytes:
- Thyroid Hormone Receptor alpha
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
Description
| Product Name: | Thyroid Hormone Receptor alpha Transcription Factor Activity Assay |
| Product Code: | TFAB00173 |
| Target: | Thyroid Hormone Receptor alpha |
| Synonyms: | Nuclear receptor subfamily 1 group A member 1, V-erbA-related protein 7, EAR-7, c-erbA-1, c-erbA-alpha |
| Reactivity: | Human, Mouse, Rat |
| Sample Types: | Nuclear or cell lysates |
The Assay Genie Thyroid Hormone Receptor alpha transcription factor activity assay allows for the detection and qualitative analysis of endogenous levels of activated transcription factors in a variety of nuclear and cell lysates
Assay Genie ELISA kits are designed to significantly reduce experiment time and ensure sensitivity and flexibility for high-throughput screening.
| Assay Time: | 4.5 hours |
| Detection Method: | Colorimetric 450 nm |
| Size: | 12 x 8-Well Microstrips |
| Storage: | 4°C for 6 months |
| UniProt Protein Function: | TR-alpha: nuclear hormone receptor and transcription factor. High affinity receptor for triiodothyronine. Interacts with SRC-3 and NCOA6 coactivators, leading to a strong increase of transcription of target genes. Four splice variant isoforms have been described. |
| UniProt Protein Details: | Protein type:DNA-binding; Nuclear receptor; Transcription factor Chromosomal Location of Human Ortholog: 17q11.2 Cellular Component: nucleoplasm; cytosol; nucleus Molecular Function:protein domain specific binding; protein binding; zinc ion binding; sequence-specific DNA binding; TATA-binding protein binding; chromatin DNA binding; protein complex binding; steroid hormone receptor activity; thyroid hormone receptor activity; transcription factor activity; transcription factor binding Biological Process: transcription from RNA polymerase II promoter; transcription initiation from RNA polymerase II promoter; negative regulation of transcriptional preinitiation complex assembly; ossification; cytoplasmic sequestering of transcription factor; intracellular receptor-mediated signaling pathway; hormone-mediated signaling; positive regulation of female receptivity; regulation of myeloid cell apoptosis; regulation of lipid catabolic process; regulation of heart contraction; regulation of transcription from RNA polymerase II promoter; female courtship behavior; learning and/or memory; thyroid gland development; erythrocyte differentiation; steroid hormone mediated signaling; gene expression; positive regulation of transcription from RNA polymerase II promoter; response to cold; negative regulation of transcription, DNA-dependent; cartilage condensation Disease: Hypothyroidism, Congenital, Nongoitrous, 6 |
| NCBI Summary: | The protein encoded by this gene is a nuclear hormone receptor for triiodothyronine. It is one of the several receptors for thyroid hormone, and has been shown to mediate the biological activities of thyroid hormone. Knockout studies in mice suggest that the different receptors, while having certain extent of redundancy, may mediate different functions of thyroid hormone. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P10827 |
| NCBI GenInfo Identifier: | 135705 |
| NCBI Gene ID: | 7067 |
| NCBI Accession: | P10827.1 |
| UniProt Secondary Accession: | P10827,P21205, Q8N6A1, Q96H73, A8K3B5, |
| UniProt Related Accession: | P10827 |
| Molecular Weight: | 50,465 Da |
| NCBI Full Name: | Thyroid hormone receptor alpha |
| NCBI Synonym Full Names: | thyroid hormone receptor, alpha |
| NCBI Official Symbol: | THRA |
| NCBI Official Synonym Symbols: | AR7; EAR7; ERBA; CHNG6; ERBA1; NR1A1; THRA1; THRA2; ERB-T-1; c-ERBA-1 |
| NCBI Protein Information: | thyroid hormone receptor alpha; EAR-7; c-erbA-alpha; ERBA-related 7; V-erbA-related protein 7; triiodothyronine receptor; nuclear receptor subfamily 1 group A member 1; thyroid normone nuclear receptor alpha variant 1; thyroid hormone receptor, alpha (erythroblastic leukemia viral (v-erb-a) oncogene homolog, avian) |
| UniProt Protein Name: | Thyroid hormone receptor alpha |
| UniProt Synonym Protein Names: | Nuclear receptor subfamily 1 group A member 1; V-erbA-related protein 7; EAR-7; c-erbA-1; c-erbA-alpha |
| Protein Family: | Thyroid hormone receptor |
| UniProt Gene Name: | THRA |
| UniProt Entry Name: | THA_HUMAN |
