Hormones Recombinant Proteins

Thymosin beta 4 Recombinant Protein (RPPB1379)

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SKU:
RPPB1379
Product Type:
Recombinant Protein
Uniprot:
P62328
Research Area:
Hormones

Description

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Product Name:Thymosin beta 4 Recombinant Protein
Product Code:RPPB1379
Size:5mg
Target:Thymosin beta 4
Synonyms:Thymosin beta-4, T beta 4, Fx , TB4X, PTMB4, TMSB4.
Physical Appearance:Sterile Filtered White lyophilized (freeze-dried) powder.
Formulation:The protein (1mg/ml) was lyophilized with no additives.
Solubility:It is recommended to reconstitute the lyophilized Thymosin beta-4 in sterile 18M?-cm H2O not less than 100 �g/ml, which can then be further diluted to other aqueous solutions.
Stability:Lyophilized Thymosin b4 although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution T beta 4 should be stored at 4°C between 2-7 days and for future use below -18°C.For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Please prevent freeze-thaw cycles.
Purity:Greater than 98.0% as determined by RP-HPLC.
Amino Acid Sequence:Thymosin b4 has an aa sequence of Ac-Ser-Asp-Lys-Pro-Asp-Met-Ala-Glu-Ile-Glu-Lys-Phe-Asp-Lys-Ser-Lys-Leu-Lys-Lys-Thr-Glu-Thr-Gln-Glu-Lys-Asn-Pro-Leu-Pro-Ser-Lys-Glu-Thr-Ile-Glu-Gln-Glu-Lys-Gln-Ala-Gly-Glu-Ser-OH

Thymosin is a hormone secreted from the thymus. Its primary function is to stimulate the production of T cells, which are an important part of the immune system.Thymosin also assists in the development of B cells to plasma cells to produce antibodies.The predominant form of thymosin, thymosin b4, is a member of a highly conserved family of actin monomer-sequestering proteins. b-thymosins are the primary regulators of unpolymerized actin, and are essential for maintaining the small cytoplasmic pool of free G-actin monomers required for rapid filament elongation and allowing for the flux of monomers between the thymosin-bound pool and F-actin.

Thymosin b4 is a 43 amino acid peptide which is regarded as the main intracellular G-actin sequestering peptide. It has a molecular weight of 4963.55 Da, and its molecular formula is: C212H350N56O78S1. Extracellular Thymosin b4 may contribute to physiological processes such as angiogenesis, wound healing, and regulation of inflammation.

UniProt Protein Function:TMSB4X: Plays an important role in the organization of the cytoskeleton. Binds to and sequesters actin monomers (G actin) and therefore inhibits actin polymerization. Belongs to the thymosin beta family.
UniProt Protein Details:

Protein type:Motility/polarity/chemotaxis; Cytoskeletal

Chromosomal Location of Human Ortholog: Xq21.3-q22

Cellular Component: cytoskeleton; extracellular region

Molecular Function:actin monomer binding; protein binding

Biological Process: platelet activation; platelet degranulation; sequestering of actin monomers; actin filament organization; blood coagulation

NCBI Summary:This gene encodes an actin sequestering protein which plays a role in regulation of actin polymerization. The protein is also involved in cell proliferation, migration, and differentiation. This gene escapes X inactivation and has a homolog on chromosome Y. [provided by RefSeq, Jul 2008]
UniProt Code:P62328
NCBI GenInfo Identifier:78103211
NCBI Gene ID:7114
NCBI Accession:P62328.2
UniProt Secondary Accession:P62328,P01253, P01254, Q546P5, Q63576, Q9UE55,
UniProt Related Accession:P62328
Molecular Weight:44
NCBI Full Name:Thymosin beta-4
NCBI Synonym Full Names:thymosin beta 4, X-linked
NCBI Official Symbol:TMSB4X��
NCBI Official Synonym Symbols:FX; TB4X; PTMB4; TMSB4��
NCBI Protein Information:thymosin beta-4; t beta-4; prothymosin beta-4; thymosin, beta 4, X chromosome
UniProt Protein Name:Thymosin beta-4
UniProt Synonym Protein Names:FxHematopoietic system regulatory peptideAlternative name(s):Seraspenide
Protein Family:Thymosin
UniProt Gene Name:TMSB4X��
UniProt Entry Name:TYB4_HUMAN
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