Hormones Recombinant Proteins

Thymosin ?1 Recombinant Protein (RPPB1378)

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SKU:
RPPB1378
Product Type:
Recombinant Protein
Uniprot:
P06454
Research Area:
Hormones

Description

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Product Name:Thymosin ?1 Recombinant Protein
Product Code:RPPB1378
Size:5mg
Target:Thymosin ?1
Physical Appearance:Sterile Filtered White lyophilized (freeze-dried) powder.
Formulation:The protein (1mg/ml) was lyophilized with no additives.
Solubility:It is recommended to reconstitute the lyophilized Thymosin a1 in sterile 18M?-cm H2O not less than 100 �g/ml, which can then be further diluted to other aqueous solutions.
Stability:Lyophilized Thymosin a1 although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution Thymalfasin should be stored at 4°C between 2-7 days and for future use below -18°C.For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Please prevent freeze-thaw cycles.
Purity:Greater than 99.0% as determined by:(a) Analysis by RP-HPLC.(b) Analysis by SDS-PAGE.

Thymalfasin is a synthetic analogue of thymosin-alpha-1, a 28-amino acid protein derived from the precursor protein prothymosin-alpha. Exhibiting a variety of immunoregulating properties, thymosin-alpha-1 induces differentiation of murine T-cell precursors and human thymocytes and the terminal differentiation of functionally immature cord blood lymphocytes and induces production of IL-2, high affinity IL-2 receptors, and B-cell growth factors by peripheral blood mononuclear cells. T-helper and cytotoxic/suppressor T-cell populations are targets of thymosin activity. Thymosin-alpha-1 has been shown to increase the efficiency of antigen presentation by macrophages and to be an endogenous modulator of alpha-thrombin activity.

Thymosin a1 acetate, also known as thymalfasin has immunoregulatory properties enhancing immune functions. Thymosin a1 has a molecular formula of C129H215N33O55 a.a. sequence of Ac-Ser-Asp-Ala-Ala-Val-Asp-Thr-Ser-Ser-Glu-Ile-Thr-Thr-Lys-Asp-Leu-Lys-Glu-Lys-Lys-Glu-Val-Val-Glu-Glu-Ala-Glu-Asn-OH and having a Mw of 3108.32 Dalton.

UniProt Protein Function:PTMA: Prothymosin alpha may mediate immune function by conferring resistance to certain opportunistic infections. Belongs to the pro/parathymosin family. 2 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Cell cycle regulation; Nuclear receptor co-regulator

Chromosomal Location of Human Ortholog: 2q37.1

Cellular Component: cytoplasm; nucleoplasm; nucleus

Molecular Function:protein binding

Biological Process: transcription, DNA-dependent

UniProt Code:P06454
NCBI GenInfo Identifier:135834
NCBI Gene ID:5757
NCBI Accession:P06454.2
UniProt Secondary Accession:P06454,Q15249, Q15592,
UniProt Related Accession:P06454
Molecular Weight:12,074 Da
NCBI Full Name:Prothymosin alpha
NCBI Synonym Full Names:prothymosin, alpha
NCBI Official Symbol:PTMA��
NCBI Official Synonym Symbols:TMSA��
NCBI Protein Information:prothymosin alpha
UniProt Protein Name:Prothymosin alpha
Protein Family:Prothymosin
UniProt Gene Name:PTMA��
UniProt Entry Name:PTMA_HUMAN
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