THNSL2 Antibody (PACO59213)
- SKU:
- PACO59213
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Applications:
- WB
- Applications:
- IHC
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | THNSL2 Antibody (PACO59213) |
| Antibody SKU: | PACO59213 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB, IHC |
| Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:500-1:5000, IHC:1:200-1:500 |
| Species Reactivity: | Human |
| Immunogen: | Recombinant Human Threonine synthase-like 2 protein (295-441AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
| Purification Method: | >95%, Protein G purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Western Blot. Positive WB detected in: Hela whole cell lysate, HepG2 whole cell lysate. All lanes: THNSL2 antibody at 4.3µg/ml. Secondary. Goat polyclonal to rabbit IgG at 1/50000 dilution. Predicted band size: 55, 46, 43, 48, 28 kDa. Observed band size: 55 kDa. |
 | IHC image of PACO59213 diluted at 1:400 and staining in paraffin-embedded human ovarian cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system. |
| Background: | Isoform 1: Acts as a catabolic phospho-lyase on both gamma- and beta-phosphorylated substrates. Degrades O-phospho-threonine (PThr) to alpha-ketobutyrate, ammonia and phosphate (By similarity). |
| Synonyms: | Threonine synthase-like 2 (TSH2) (EC 4.2.3) (Secreted osteoclastogenic factor of activated T-cells) (SOFAT), THNSL2 |
| UniProt Protein Function: | Isoform 1: Acts as a catabolic phospho-lyase on both gamma- and beta-phosphorylated substrates. Degrades O-phospho-threonine (PThr) to alpha-ketobutyrate, ammonia and phosphate (). |
| UniProt Protein Details: | |
| NCBI Summary: | This gene encodes a threonine synthase-like protein. A similar enzyme in mouse can catalyze the degradation of O-phospho-homoserine to a-ketobutyrate, phosphate, and ammonia. This protein also has phospho-lyase activity on both gamma and beta phosphorylated substrates. In mouse an alternatively spliced form of this protein has been shown to act as a cytokine and can induce the production of the inflammatory cytokine IL6 in osteoblasts. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2011] |
| UniProt Code: | Q86YJ6 |
| NCBI GenInfo Identifier: | 347658949 |
| NCBI Gene ID: | 55258 |
| NCBI Accession: | NP_001231605.1 |
| UniProt Secondary Accession: | Q86YJ6,Q6P2M7, Q6PI27, Q9NV54, B3KTB1, B5MDX8, B7WPF8 D9ZZB8 |
| UniProt Related Accession: | Q86YJ6 |
| Molecular Weight: | 53 |
| NCBI Full Name: | threonine synthase-like 2 isoform 2 |
| NCBI Synonym Full Names: | threonine synthase like 2 |
| NCBI Official Symbol: | THNSL2 |
| NCBI Official Synonym Symbols: | THS2; TSH2; SOFAT |
| NCBI Protein Information: | threonine synthase-like 2 |
| UniProt Protein Name: | Threonine synthase-like 2 |
| UniProt Synonym Protein Names: | Secreted osteoclastogenic factor of activated T-cells; SOFAT |
| Protein Family: | |
| UniProt Gene Name: | THNSL2 |
| UniProt Entry Name: |
| Antibodies |
| THNSL2 Antibody (PACO12740) |
| Secondary Antibody |
| Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
| Recommended Products |
| Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
| Anti-HRP-conjugated Beta Actin Antibody (CABC028) |
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