Description
| Antibody Name: | THAP6 Antibody (PACO17232) |
| Antibody SKU: | PACO17232 |
| Size: | 50ul |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, IHC |
| Recommended Dilutions: | ELISA:1:2000-1:5000, IHC:1:25-1:100 |
| Species Reactivity: | Human |
| Immunogen: | Full length fusion protein |
| Form: | Liquid |
| Storage Buffer: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
| Purification Method: | Antigen affinity purification |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
![]() | The image on the left is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using PACO17232(THAP6 Antibody) at dilution 1/25, on the right is treated with fusion protein. (Original magnification: x200). |
| Background: | THAP6 (THAP domain-containing protein 6) is a 222 amino acid, protein that contains one THAP-type zinc finger and exists as two alternatively spliced isoforms. The gene that encodes THAP6 consists of approximately 36,528 bases and maps to human chromosome 4q21.1. Chromosome 4 represents approximately 6% of the human genome and contains nearly 900 genes. Notably, the Huntingtin gene, which is found to encode an expanded glutamine tract in cases of Huntington's disease, is encoded by a gene that maps to chromosome 4. FGFR-3 is also encoded by a gene located on chromosome 4 and has been associated with thanatophoric dwarfism, achondroplasia, Muenke syndrome and bladder cancer. Chromosome 4 is also tied to Ellis-van Creveld syndrome, methylmalonic acid, mia and polycystic kidney disease. |
| Synonyms: | THAP domain containing 6 |
| UniProt Protein Function: | THAP6: 2 isoforms of the human protein are produced by alternative splicing.Chromosomal Location of Human Ortholog: 4q21.1Cellular Component: microtubule cytoskeletonMolecular Function: DNA binding; metal ion binding |
| UniProt Protein Details: | |
| NCBI Summary: | |
| UniProt Code: | Q8TBB0 |
| NCBI GenInfo Identifier: | 21389507 |
| NCBI Gene ID: | 152815 |
| NCBI Accession: | NP_653322.1 |
| UniProt Secondary Accession: | Q8TBB0,Q5HYJ7, Q5JPC6, B4E146 |
| UniProt Related Accession: | Q8TBB0 |
| Molecular Weight: | 18,511 Da |
| NCBI Full Name: | THAP domain-containing protein 6 |
| NCBI Synonym Full Names: | THAP domain containing 6 |
| NCBI Official Symbol: | THAP6 |
| NCBI Official Synonym Symbols: | |
| NCBI Protein Information: | THAP domain-containing protein 6 |
| UniProt Protein Name: | THAP domain-containing protein 6 |
| UniProt Synonym Protein Names: | |
| Protein Family: | THAP domain-containing protein |
| UniProt Gene Name: | THAP6 |
| UniProt Entry Name: | THAP6_HUMAN |
