TGM6 Antibody (PACO20749)
- SKU:
- PACO20749
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Applications:
- IHC
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | TGM6 Antibody (PACO20749) |
| Antibody SKU: | PACO20749 |
| Size: | 50ul |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, IHC |
| Recommended Dilutions: | ELISA:1:2000-1:5000, IHC:1:25-1:100 |
| Species Reactivity: | Human |
| Immunogen: | Synthetic peptide of human TGM6 |
| Form: | Liquid |
| Storage Buffer: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
| Purification Method: | Antigen affinity purification |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | The image on the left is immunohistochemistry of paraffin-embedded Human lung cancer tissue using PACO20749(TGM6 Antibody) at dilution 1/35, on the right is treated with synthetic peptide. (Original magnification: x200). |
| Background: | The protein encoded by this gene belongs to the transglutaminase superfamily. It catalyzes the cross-linking of proteins and the conjugation of polyamines to proteins. Mutations in this gene are associated with spinocerebellar ataxia type 35 (SCA35). Alternatively spliced transcript variants encoding different isoforms have been found for this gene. |
| Synonyms: | transglutaminase 6 |
| UniProt Protein Function: | TGM6: an enzyme of the transglutaminase family that catalyzes the crosslinking of proteins and the conjugation of polyamines to proteins. While the primary structure of transglutaminases is not conserved, they all have the same amino acid sequence at their active sites and their activity is calcium-dependent. Two alternatively spliced isoforms have been described. |
| UniProt Protein Details: | Protein type:Transferase; EC 2.3.2.13 Chromosomal Location of Human Ortholog: 20p13 Cellular Component: cytoplasm Molecular Function:protein-glutamine gamma-glutamyltransferase activity; metal ion binding Biological Process: peptide cross-linking Disease: Spinocerebellar Ataxia 35 |
| NCBI Summary: | The protein encoded by this gene belongs to the transglutaminase superfamily. It catalyzes the cross-linking of proteins and the conjugation of polyamines to proteins. Mutations in this gene are associated with spinocerebellar ataxia type 35 (SCA35). Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011] |
| UniProt Code: | O95932 |
| NCBI GenInfo Identifier: | 119631005 |
| NCBI Gene ID: | 343641 |
| NCBI Accession: | EAX10600.1 |
| UniProt Secondary Accession: | O95932,Q5JXU4, Q5JXU5, Q719M2, Q719M3, Q9Y4U8, |
| UniProt Related Accession: | O95932 |
| Molecular Weight: | 70,516 Da |
| NCBI Full Name: | transglutaminase 6, partial |
| NCBI Synonym Full Names: | transglutaminase 6 |
| NCBI Official Symbol: | TGM6 |
| NCBI Official Synonym Symbols: | TG6; TGY; SCA35; TGM3L; dJ734P14.3 |
| NCBI Protein Information: | protein-glutamine gamma-glutamyltransferase 6 |
| UniProt Protein Name: | Protein-glutamine gamma-glutamyltransferase 6 |
| UniProt Synonym Protein Names: | Transglutaminase Y; TGY; TGase Y; Transglutaminase-3-like; TGase-3-like; Transglutaminase-6; TG6; TGase-6 |
| Protein Family: | Protein-glutamine gamma-glutamyltransferase |
| UniProt Gene Name: | TGM6 |
| UniProt Entry Name: | TGM3L_HUMAN |
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