Name: TGIF2 Antibody (PACO53190)
SKU: PACO53190
Availability: OutOfStock

Antibody Name:	TGIF2 Antibody (PACO53190)
Antibody SKU:	PACO53190
Size:	50ug
Host Species:	Rabbit
Tested Applications:	ELISA, IHC, IF
Recommended Dilutions:	ELISA:1:2000-1:10000, IHC:1:20-1:200, IF:1:50-1:200
Species Reactivity:	Human
Immunogen:	Recombinant Human Homeobox protein TGIF2 protein (82-222AA)

Form:	Liquid
Storage Buffer:	Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Purification Method:	>95%, Protein G purified
Clonality:	Polyclonal
Isotype:	IgG
Conjugate:	Non-conjugated

	Immunohistochemistry of paraffin-embedded human kidney tissue using PACO53190 at dilution of 1:100.
	Immunofluorescent analysis of HepG2 cells using PACO53190 at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).

Background:	Transcriptional repressor, which probably repress transcription by binding directly the 5'-CTGTCAA-3' DNA sequence or by interacting with TGF-β activated SMAD proteins. Probably represses transcription via the recruitment of histone deacetylase proteins.
Synonyms:	Homeobox protein TGIF2 (5'-TG-3'-interacting factor 2) (TGF-beta-induced transcription factor 2) (TGFB-induced factor 2), TGIF2

UniProt Protein Function:	TGIF2: Transcriptional repressor, which probably repress transcription by binding directly the 5'-CTGTCAA-3' DNA sequence or by interacting with TGF-beta activated SMAD proteins. Probably represses transcription via the recruitment of histone deacetylase proteins. Belongs to the TALE/TGIF homeobox family.Protein type: DNA-bindingChromosomal Location of Human Ortholog: 20q11.23Cellular Component: nucleoplasm; nucleusBiological Process: negative regulation of transcription from RNA polymerase II promoter
UniProt Protein Details:
NCBI Summary:	The protein encoded by this gene is a DNA-binding homeobox protein and a transcriptional repressor, which appears to repress transcription by recruiting histone deacetylases to TGF beta-responsive genes. This gene is amplified and over-expressed in some ovarian cancers. Alternative splicing results in multiple transcript variants. A related pseudogene has been identified on chromosome 1. Read-through transcription also exists between this gene and the neighboring downstream C20orf24 (chromosome 20 open reading frame 24) gene. [provided by RefSeq, Dec 2010]
UniProt Code:	Q9GZN2
NCBI GenInfo Identifier:	27805750
NCBI Gene ID:	60436
NCBI Accession:	Q9GZN2.1
UniProt Secondary Accession:	Q9GZN2,B2R9U3, E1P5T9, H0YNI0
UniProt Related Accession:	Q9GZN2
Molecular Weight:	17,908 Da
NCBI Full Name:	Homeobox protein TGIF2
NCBI Synonym Full Names:	TGFB induced factor homeobox 2
NCBI Official Symbol:	TGIF2
NCBI Official Synonym Symbols:
NCBI Protein Information:	homeobox protein TGIF2
UniProt Protein Name:	Homeobox protein TGIF2
UniProt Synonym Protein Names:	5'-TG-3'-interacting factor 2; TGF-beta-induced transcription factor 2; TGFB-induced factor 2
Protein Family:	Homeobox protein
UniProt Gene Name:	TGIF2
UniProt Entry Name:	TGIF2_HUMAN