Antibody Name:	TGFB1 Antibody (PACO30346)
Antibody SKU:	PACO30346
Size:	50ug
Host Species:	Rabbit
Tested Applications:	ELISA
Recommended Dilutions:
Species Reactivity:	Bovine
Immunogen:	Recombinant Bovine Transforming growth factor beta-1 proprotein protein (279-390AA)

Form:	Liquid
Storage Buffer:	Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Purification Method:	>95%, Protein G purified
Clonality:	Polyclonal
Isotype:	IgG
Conjugate:	Non-conjugated

Background:

Multifunctional protein that controls proliferation, differentiation and other functions in many cell types. Many cells synthesize TGFB1 and have specific receptors for it. It positively and negatively regulates many other growth factors. It plays an important role in bone remodeling as it is a potent stimulator of osteoblastic bone formation, causing chemotaxis, proliferation and differentiation in committed osteoblasts (By similarity).

Synonyms:

Transforming growth factor beta-1 proprotein [Cleaved into: Latency-associated peptide (LAP)], (Transforming growth factor beta-1) (TGF-beta-1) TGFB1

UniProt Protein Function:	Multifunctional protein that controls proliferation, differentiation and other functions in many cell types. Many cells synthesize TGFB1 and have specific receptors for it. It positively and negatively regulates many other growth factors. It plays an important role in bone remodeling as it is a potent stimulator of osteoblastic bone formation, causing chemotaxis, proliferation and differentiation in committed osteoblasts (). Stimulates sustained production of collagen through the activation of CREB3L1 by regulated intramembrane proteolysis (RIP) (). Can promote either T-helper 17 cells (Th17) or regulatory T-cells (Treg) lineage differentiation in a concentration-dependent manner. At high concentrations, leads to FOXP3-mediated suppression of RORC and down-regulation of IL-17 expression, favoring Treg cell development. At low concentrations in concert with IL-6 and IL-21, leads to expression of the IL-17 and IL-23 receptors, favoring differentiation to Th17 cells. Mediates SMAD2/3 activation by inducing its phosphorylation and subsequent translocation to the nucleus. Can induce epithelial-to-mesenchymal transition (EMT) and cell migration in various cell types ().
UniProt Protein Details:
NCBI Summary:
UniProt Code:	P18341
NCBI GenInfo Identifier:	260655603
NCBI Gene ID:	282089
NCBI Accession:	NP_001159540.1
UniProt Secondary Accession:	P18341,A5A3B8
UniProt Related Accession:	P18341
Molecular Weight:	44,409 Da
NCBI Full Name:	transforming growth factor beta-1
NCBI Synonym Full Names:	transforming growth factor beta 1
NCBI Official Symbol:	TGFB1
NCBI Official Synonym Symbols:
NCBI Protein Information:	transforming growth factor beta-1
UniProt Protein Name:	Transforming growth factor beta-1
UniProt Synonym Protein Names:
Protein Family:	Transforming growth factor
UniProt Gene Name:	TGFB1
UniProt Entry Name: