TGF beta Receptor II (TGFBR2) Monoclonal Antibody

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SKU:
CAB22471
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Human
Reactivity:
Mouse
Host Species:
Rabbit
Isotype:
IgG
Applications:
IHC

Description

Product Name:TGF beta Receptor II (TGFBR2) Monoclonal Antibody
Product Code:CAB22471
Reactivity:Human, Mouse
Applications:Immunohistochemistry
Host Species:Rabbit
Purification Method:Affinity purification
Isotype:IgG
Clone No:ARC57218
Reactivity:Human, Mouse
Tested Applications:IHC-P, ELISA
Key Applications:Immunohistochemistry
Recommended Dilution:IHC-P 1:50-1:200
Storage Buffer:Store at -20°C. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300, 0.05% BSA, 50% glycerol, pH7.3.
Cellular Location:Cell membrane, Single-pass type I membrane protein

The protein encoded by this gene is a transmembrane protein that has a protein kinase domain, forms a heterodimeric complex with TGF-beta receptor type-1, and binds TGF-beta. This receptor/ligand complex phosphorylates proteins, which then enter the nucleus and regulate the transcription of genes related to cell proliferation, cell cycle arrest, wound healing, immunosuppression, and tumorigenesis. Mutations in this gene have been associated with Marfan Syndrome, Loeys-Deitz Aortic Aneurysm Syndrome, and the development of various types of tumors. Alternatively spliced transcript variants encoding different isoforms have been characterized.

Immunogen:A synthetic peptide corresponding to a sequence within amino acids 200-300 of human TGF beta Receptor II (TGFBR2) (NP_003233.4).
Sequence:TWETG KTRKL MEFSE HCAII LEDDR SDISS TCANN INHNT ELLPI ELDTL VGKGR FAEVY KAKLK QNTSE QFETV AVKIF PYEEY ASWKT EKDIF SDINL K
Synonyms:AAT3, FAA3, LDS2, MFS2, RIIC, LDS1B, LDS2B, TAAD2, TBRII, TBR-ii, TGFR-2, tbetaR-II, TGFbeta-RII
Calculated MW:65kDa
Observed MW:Refer to figures
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