TGF beta 1 Monoclonal Antibody (CAB22296)
- SKU:
- CAB22296
- Product Type:
- Antibody
- Antibody Type:
- Monoclonal Antibody
- Reactivity:
- Human
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- WB
- Applications:
- IF
Description
| Product Name: | TGF beta 1 Monoclonal Antibody |
| Product Code: | CAB22296 |
| Reactivity: | Human, Rat |
| Applications: | Western blotting, Immunofluorescence |
| Host Species: | Rabbit |
| Purification Method: | Affinity purification |
| Isotype: | IgG |
| Clone No: | ARC57012 |
| Reactivity: | Human, Rat |
| Tested Applications: | WB, IF/ICC, ELISA |
| Key Applications: | Western blotting, Immunofluorescence |
| Recommended Dilution: | WB 1:2000-1:7000, IF/ICC 1:500-1:1000 |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300, 0.05% BSA, 50% glycerol, pH7.3. |
| Positive Samples: | U-2 OS |
| Cellular Location: | Secreted, Extracellular matrix, Extracellular space |
This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate a latency-associated peptide (LAP) and a mature peptide, and is found in either a latent form composed of a mature peptide homodimer, a LAP homodimer, and a latent TGF-beta binding protein, or in an active form consisting solely of the mature peptide homodimer. The mature peptide may also form heterodimers with other TGFB family members. This encoded protein regulates cell proliferation, differentiation and growth, and can modulate expression and activation of other growth factors including interferon gamma and tumor necrosis factor alpha. This gene is frequently upregulated in tumor cells, and mutations in this gene result in Camurati-Engelmann disease.
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 30-390 of human TGF beta 1 (NP_000651.3). |
| Sequence: | LSTCK TIDME LVKRK RIEAI RGQIL SKLRL ASPPS QGEVP PGPLP EAVLA LYNST RDRVA GESAE PEPEP EADYY AKEVT RVLMV ETHNE IYDKF KQSTH SIYMF FNTSE LREAV PEPVL LSRAE LRLLR LKLKV EQHVE LYQKY SNNSW RYLSN RLLAP SDSPE WLSFD VTGVV RQWLS RGGEI EGFRL SAHCS CDSRD NTLQV DINGF TTGRR GDLAT IHGMN RPFLL LMATP LERAQ HLQSS RHRRA LDTNY CFSST EKNCC VRQLY IDFRK DLGWK WIHEP KGYHA NFCLG PCPYI WSLDT QYSKV LALYN QHNPG ASAAP CCVPQ ALEPL PIVYY VGRKP KVEQL SNMIV RSCKC S |
| Synonyms: | CED, LAP, DPD1, TGFB, IBDIMDE, TGFbeta, TGF-beta1 |
| Calculated MW: | 44kDa |
| Observed MW: | 45-60kDa |
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