UniProt Protein Function: | TGDS: Belongs to the sugar epimerase family. dTDP-glucose dehydratase subfamily.Protein type: EC 4.2.1.46; LyaseChromosomal Location of Human Ortholog: 13q32.1Molecular Function: coenzyme binding; dTDP-glucose 4,6-dehydratase activityBiological Process: nucleotide-sugar metabolic processDisease: Catel-manzke Syndrome |
UniProt Protein Details: | |
NCBI Summary: | The protein encoded by this gene is a member of the short-chain dehydrogenases/reductases (SDR) superfamily, and is thought to contain a nicotinamide adenine dinucleotide (NAD) binding domain. This large SDR family of enzymes is involved in the metabolism of a variety of compounds, including prostaglandins, retinoids, lipids, steroid hormones, and xenobiotics. Mutations in this gene have been associated with Catel-Manzke syndrome, which is characterized by Pierre Robin sequence, and radial deviation of the index finger due to the presence of an accessory bone between the index finger and its proximal phalanx. Pierre Robin sequence is defined by an undersized jaw, backwards displacement of the tongue base that causes an obstruction of the airways, and can also be associated with a cleft palate. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2015] |
UniProt Code: | O95455 |
NCBI GenInfo Identifier: | 7657641 |
NCBI Gene ID: | 23483 |
NCBI Accession: | NP_055120.1 |
UniProt Secondary Accession: | O95455,Q05DQ3, Q2TU31, Q5T3Z2, Q9H1T9 |
UniProt Related Accession: | O95455 |
Molecular Weight: | 40,214 Da |
NCBI Full Name: | dTDP-D-glucose 4,6-dehydratase |
NCBI Synonym Full Names: | TDP-glucose 4,6-dehydratase |
NCBI Official Symbol: | TGDS |
NCBI Official Synonym Symbols: | TDPGD; SDR2E1 |
NCBI Protein Information: | dTDP-D-glucose 4,6-dehydratase; growth-inhibiting protein 21; short chain dehydrogenase/reductase family 2E, member 1 |
UniProt Protein Name: | dTDP-D-glucose 4,6-dehydratase |
UniProt Synonym Protein Names: | |
Protein Family: | dTDP-D-glucose 4,6-dehydratase |
UniProt Gene Name: | TGDS |
UniProt Entry Name: | TGDS_HUMAN |