TFEC Antibody (PACO12716)
- SKU:
- PACO12716
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Applications:
- WB
- Applications:
- IHC
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | TFEC Antibody (PACO12716) |
| Antibody SKU: | PACO12716 |
| Size: | 50ul |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB, IHC |
| Recommended Dilutions: | |
| Species Reactivity: | Human, Mouse, Rat |
| Immunogen: | Human TFEC |
| Form: | Liquid |
| Storage Buffer: | PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles. |
| Purification Method: | Antigen Affinity Purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
| Synonyms: | transcription factor EC;TFEC;TCFEC;TFECL;bHLHe34 ; |
| UniProt Protein Function: | TFEC: Transcriptional regulator that acts as a repressor or an activator. Acts as a transcriptional repressor on minimal promoter containing element F (that includes an E-box sequence). Binds to element F in an E-box sequence-specific manner. Acts as a transcriptional transactivator on the proximal promoter region of the tartrate-resistant acid phosphatase (TRAP) E-box containing promoter. Collaborates with MITF in target gene activation. Acts as a transcriptional repressor on minimal promoter containing mu E3 enhancer sequence. Binds to mu E3 DNA sequence of the immunoglobulin heavy-chain gene enhancer. Binds DNA in a homo- or heterodimeric form. Belongs to the MiT/TFE family. 4 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:DNA-binding Chromosomal Location of Human Ortholog: 7q31.2 Cellular Component: nucleoplasm; cytoplasm Molecular Function:protein dimerization activity; DNA binding; transcription coactivator activity; transcription corepressor activity; transcription factor activity Biological Process: regulation of transcription, DNA-dependent; transcription, DNA-dependent |
| NCBI Summary: | This gene encodes a member of the micropthalmia (MiT) family of basic helix-loop-helix leucine zipper transcription factors. MiT transcription factors regulate the expression of target genes by binding to E-box recognition sequences as homo- or heterodimers, and play roles in multiple cellular processes including survival, growth and differentiation. The encoded protein is a transcriptional activator of the nonmuscle myosin II heavy chain-A gene, and may also co-regulate target genes in osteoclasts as a heterodimer with micropthalmia-associated transcription factor. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Sep 2011] |
| UniProt Code: | O14948 |
| NCBI GenInfo Identifier: | 74705481 |
| NCBI Gene ID: | 22797 |
| NCBI Accession: | O14948.1 |
| UniProt Secondary Accession: | O14948,Q5H9U8, Q709A4, Q8N6J9, B2R8X5, |
| UniProt Related Accession: | O14948 |
| Molecular Weight: | 347 |
| NCBI Full Name: | Transcription factor EC |
| NCBI Synonym Full Names: | transcription factor EC |
| NCBI Official Symbol: | TFEC |
| NCBI Official Synonym Symbols: | TCFEC; TFE-C; TFECL; TFEC-L; bHLHe34; hTFEC-L |
| NCBI Protein Information: | transcription factor EC; class E basic helix-loop-helix protein 34 |
| UniProt Protein Name: | Transcription factor EC |
| UniProt Synonym Protein Names: | Class E basic helix-loop-helix protein 34; bHLHe34; Transcription factor EC-like; hTFEC-L |
| Protein Family: | Transcription factor |
| UniProt Gene Name: | TFEC |
| UniProt Entry Name: | TFEC_HUMAN |
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