tetX Antibody (PACO34670)
- SKU:
- PACO34670
- Product Type:
- Antibody
- Reactivity:
- Bacteria
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | tetX Antibody (PACO34670) |
| Antibody SKU: | PACO34670 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA |
| Recommended Dilutions: | |
| Species Reactivity: | Clostridium tetani |
| Immunogen: | Recombinant Clostridium tetani Tetanus toxin protein (123-573AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
| Purification Method: | >95%, Protein G purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
| Background: | Tetanus toxin acts by inhibiting neurotransmitter release. It binds to peripheral neuronal synapses, is internalized and moves by retrograde transport up the axon into the spinal cord where it can move between postsynaptic and presynaptic neurons. It inhibits neurotransmitter release by acting as a zinc endopeptidase that catalyzes the hydrolysis of the '76-Gln- |-Phe-77' bond of synaptobrevin-2. |
| Synonyms: | Tetanus toxin (EC 3.4.24.68) (Tentoxylysin) [Cleaved into: Tetanus toxin light chain (Tetanus toxin chain L); Tetanus toxin heavy chain (Tetanus toxin chain H)], tetX |
| UniProt Protein Function: | Function: Tetanus toxin acts by inhibiting neurotransmitter release. It binds to peripheral neuronal synapses, is internalized and moves by retrograde transport up the axon into the spinal cord where it can move between postsynaptic and presynaptic neurons. It inhibits neurotransmitter release by acting as a zinc endopeptidase that catalyzes the hydrolysis of the '76-Gln-|-Phe-77' bond of synaptobrevin-2.Catalytic activity: Hydrolysis of 76-Gln-|-Phe-77 bond in synaptobrevin 2.Cofactor: Binds 1 zinc ion per subunit By similarity.Subunit structure: The precursor polypeptide is subsequently cleaved to yield subchains L and H. These remain linked by a disulfide bridge and are non-toxic after separation.Miscellaneous: The C-terminus of the heavy chain binds to ganglioside receptors.Sequence similarities: Belongs to the peptidase M27 family. |
| UniProt Protein Details: | |
| NCBI Summary: | |
| UniProt Code: | P04958 |
| NCBI GenInfo Identifier: | 135624 |
| NCBI Gene ID: | 1061100 |
| NCBI Accession: | P04958.2 |
| UniProt Secondary Accession: | P04958 |
| UniProt Related Accession: | P04958 |
| Molecular Weight: | 150,682 Da |
| NCBI Full Name: | Tetanus toxin |
| NCBI Synonym Full Names: | |
| NCBI Official Symbol: | tetX |
| NCBI Official Synonym Symbols: | |
| NCBI Protein Information: | tetanus toxin tetX |
| UniProt Protein Name: | Tetanus toxin |
| UniProt Synonym Protein Names: | Tentoxylysin |
| Protein Family: | Tetanus toxin |
| UniProt Gene Name: | tetX |
| UniProt Entry Name: | TETX_CLOTE |
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