TESPA1 Antibody (PACO27785)
- SKU:
- PACO27785
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Applications:
- IHC
- Applications:
- IF
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | TESPA1 Antibody (PACO27785) |
| Antibody SKU: | PACO27785 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, IHC, IF |
| Recommended Dilutions: | ELISA:1:2000-1:10000, IHC:1:20-1:200, IF:1:50-1:200 |
| Species Reactivity: | Human |
| Immunogen: | Recombinant Human Protein TESPA1 protein (251-521AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
| Purification Method: | >95%, Protein G purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Immunohistochemistry of paraffin-embedded human small intestine tissue using PACO27785 at dilution of 1:100. |
 | Immunofluorescent analysis of A549 cells using PACO27785 at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L). |
| Background: | Required for the development and maturation of T-cells, its function being essential for the late stages of thymocyte development. Plays a role in T-cell antigen receptor (TCR)-mediated activation of the ERK and NFAT signaling pathways, possibly by serving as a scaffolding protein that promotes the assembly of the LAT signalosome in thymocytes. May play a role in the regulation of inositol 1,4,5-trisphosphate receptor-mediated Ca(2+) release and mitochondrial Ca(2+) uptake via the mitochondria-associated endoplasmic reticulum membrane (MAM) compartment. |
| Synonyms: | Protein TESPA1 (Thymocyte-expressed positive selection-associated protein 1), TESPA1, KIAA0748 |
| UniProt Protein Function: | TESPA1: Required for the development and maturation of T-cells, its function being essential for the late stages of thymocyte development. Plays a role in T-cell antigen receptor (TCR)-mediated activation of the ERK and NFAT signaling pathways, possibly by serving as a scaffolding protein that promotes the assembly of the LAT signalosome in thymocytes. 3 isoforms of the human protein are produced by alternative splicing.Protein type: Unknown functionChromosomal Location of Human Ortholog: 12q13.2Cellular Component: signalosome; endoplasmic reticulum membrane; cytoplasmMolecular Function: receptor bindingBiological Process: positive regulation of T cell differentiation in the thymus; positive regulation of T cell receptor signaling pathway; signalosome assembly |
| UniProt Protein Details: | |
| NCBI Summary: | |
| UniProt Code: | A2RU30 |
| NCBI GenInfo Identifier: | 209862861 |
| NCBI Gene ID: | 9840 |
| NCBI Accession: | NP_001129502 |
| UniProt Secondary Accession: | A2RU30,O94849, Q4G0P2, Q9P0C4, B4DPM3, B4E048, B7Z9K7 |
| UniProt Related Accession: | A2RU30 |
| Molecular Weight: | Predicted: 57 kDaObserved: 60 kDa |
| NCBI Full Name: | protein TESPA1 isoform 1 |
| NCBI Synonym Full Names: | thymocyte expressed, positive selection associated 1 |
| NCBI Official Symbol: | TESPA1 |
| NCBI Official Synonym Symbols: | HSPC257; KIAA0748 |
| NCBI Protein Information: | protein TESPA1; thymocyte-expressed positive selection-associated protein 1 |
| UniProt Protein Name: | Protein TESPA1 |
| UniProt Synonym Protein Names: | Thymocyte-expressed positive selection-associated protein 1 |
| Protein Family: | Protein |
| UniProt Gene Name: | TESPA1 |
| UniProt Entry Name: | TESP1_HUMAN |
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