TENM3 Antibody (PACO18962)
- SKU:
- PACO18962
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Applications:
- IHC
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | TENM3 Antibody (PACO18962) |
| Antibody SKU: | PACO18962 |
| Size: | 50ul |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, IHC |
| Recommended Dilutions: | ELISA:1:5000-1:20000, IHC:1:100-1:300 |
| Species Reactivity: | Human, Mouse |
| Immunogen: | Synthetic peptide of human TENM3 |
| Form: | Liquid |
| Storage Buffer: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
| Purification Method: | Antigen affinity purification |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | The image on the left is immunohistochemistry of paraffin-embedded Human lung cancer tissue using PACO18962(TENM3 Antibody) at dilution 1/50, on the right is treated with synthetic peptide. (Original magnification: x200). |
 | The image on the left is immunohistochemistry of paraffin-embedded Human ovarian cancer tissue using PACO18962(TENM3 Antibody) at dilution 1/50, on the right is treated with synthetic peptide. (Original magnification: x200). |
| Background: | This protein involved in neural development, regulating the establishment of proper connectivity within the nervous system. It promotes axon guidance and homophilic cell adhesion. And it plays a role in the development of the visual pathway; regulates the formation in ipsilateral retinal mapping to both the dorsal lateral geniculate nucleus (dLGN) and the superior colliculus (SC). May be involved in the differentiation of the fibroblast-like cells in the superficial layer of mandibular condylar cartilage into chondrocytes. |
| Synonyms: | teneurin transmembrane protein 3 |
| UniProt Protein Function: | ODZ3: May function as a cellular signal transducer. Belongs to the tenascin family. Teneurin subfamily.Protein type: Receptor, misc.; Membrane protein, integralChromosomal Location of Human Ortholog: 4q35.1Cellular Component: axon; integral to membrane; membraneMolecular Function: protein heterodimerization activity; protein homodimerization activityBiological Process: camera-type eye morphogenesis; homophilic cell adhesion; signal transductionDisease: Microphthalmia, Isolated, With Coloboma 9 |
| UniProt Protein Details: | |
| NCBI Summary: | This gene encodes a large transmembrane protein that may be involved in the regulation of neuronal development. Mutation in this gene causes microphthalmia. [provided by RefSeq, Aug 2015] |
| UniProt Code: | Q9P273 |
| NCBI GenInfo Identifier: | 122937400 |
| NCBI Gene ID: | 55714 |
| NCBI Accession: | NP_001073946.1 |
| UniProt Secondary Accession: | Q9P273,Q5XUL9, Q96SY2, Q9NV77, Q9NVW1, Q9NZJ2 |
| UniProt Related Accession: | Q9P273 |
| Molecular Weight: | 300,950 Da |
| NCBI Full Name: | teneurin-3 |
| NCBI Synonym Full Names: | teneurin transmembrane protein 3 |
| NCBI Official Symbol: | TENM3 |
| NCBI Official Synonym Symbols: | ODZ3; TNM3; ten-3; Ten-m3; MCOPCB9 |
| NCBI Protein Information: | teneurin-3 |
| UniProt Protein Name: | Teneurin-3 |
| UniProt Synonym Protein Names: | Protein Odd Oz/ten-m homolog 3; Tenascin-M3; Ten-m3; Teneurin transmembrane protein 3 |
| Protein Family: | |
| UniProt Gene Name: | TENM3 |
| UniProt Entry Name: | TEN3_HUMAN |
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