Name: TEF Antibody (PACO01603)
SKU: PACO01603
Availability: OutOfStock

Antibody Name:	TEF Antibody
Antibody SKU:	PACO01603
Size:	50ug
Host Species:	Rabbit
Tested Applications:	ELISA, WB, IHC
Recommended Dilutions:	WB:1:500-1:2000, IHC:1:100-1:300
Species Reactivity:	Human, Mouse, Rat
Immunogen:	synthesized peptide derived from the C-terminal region of human TEF.

Form:	Liquid
Storage Buffer:	Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification Method:	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Clonality:	Polyclonal
Isotype:	IgG
Conjugate:	Non-conjugated

Synonyms:

TEF; KIAA1655; Thyrotroph embryonic factor

UniProt Protein Function:	TEF: Transcription factor that binds to and transactivates the TSHB promoter. Binds to a minimal DNA-binding sequence 5'- [TC][AG][AG]TTA[TC][AG]-3'. Belongs to the bZIP family. PAR subfamily. 2 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:	Protein type:Transcription factor; DNA-binding Chromosomal Location of Human Ortholog: 22q13.2 Cellular Component: nucleus Molecular Function:double-stranded DNA binding; protein binding; sequence-specific DNA binding; transcription factor activity Biological Process: positive regulation of transcription from RNA polymerase II promoter; regulation of transcription from RNA polymerase II promoter; rhythmic process; transcription, DNA-dependent
NCBI Summary:	This gene encodes a member of the PAR (proline and acidic amino acid-rich) subfamily of basic region/leucine zipper (bZIP) transcription factors. It is expressed in a broad range of cells and tissues in adult animals, however, during embryonic development, TEF expression appears to be restricted to the developing anterior pituitary gland, coincident with the appearance of thyroid-stimulating hormone, beta (TSHB). Indeed, TEF can bind to, and transactivate the TSHB promoter. It shows homology (in the functional domains) with other members of the PAR-bZIP subfamily of transcription factors, which include albumin D box-binding protein (DBP), human hepatic leukemia factor (HLF) and chicken vitellogenin gene-binding protein (VBP); VBP is considered the chicken homologue of TEF. Different members of the subfamily can readily form heterodimers, and share DNA-binding, and transcriptional regulatory properties. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]
UniProt Code:	Q10587
NCBI GenInfo Identifier:	51338730
NCBI Gene ID:	7008
NCBI Accession:	Q10587.3
UniProt Secondary Accession:	Q10587,Q15729, Q7Z3J7, Q8IU94, Q96TG4, B0QYS8, B2RC22
UniProt Related Accession:	Q10587
Molecular Weight:	30,635 Da
NCBI Full Name:	Thyrotroph embryonic factor
NCBI Synonym Full Names:	thyrotrophic embryonic factor
NCBI Official Symbol:	TEF
NCBI Protein Information:	thyrotroph embryonic factor
UniProt Protein Name:	Thyrotroph embryonic factor
Protein Family:	Transcription factor
UniProt Gene Name:	TEF
UniProt Entry Name:	TEF_HUMAN