TECPR2 Antibody (PACO49058)
- SKU:
- PACO49058
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Applications:
- IHC
- Applications:
- IF
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | TECPR2 Antibody (PACO49058) |
| Antibody SKU: | PACO49058 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, IHC, IF |
| Recommended Dilutions: | ELISA:1:2000-1:10000, IHC:1:20-1:200, IF:1:50-1:200 |
| Species Reactivity: | Human |
| Immunogen: | Recombinant Human Tectonin beta-propeller repeat-containing protein 2 protein (516-783AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
| Purification Method: | >95%, Protein G purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Immunohistochemistry of paraffin-embedded human pancreatic cancer using PACO49058 at dilution of 1:100. |
 | Immunofluorescent analysis of PC-3 cells using PACO49058 at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L). |
| Background: | Probably plays a role as positive regulator of autophagy. |
| Synonyms: | Tectonin beta-propeller repeat-containing protein 2 (WD repeat-containing protein KIAA0329/KIAA0297), TECPR2, KIAA0297 KIAA0329 |
| UniProt Protein Function: | TECPR2: Belongs to the WD repeat KIAA0329 family.Protein type: Unknown functionChromosomal Location of Human Ortholog: 14q32.31Molecular Function: protein bindingDisease: Spastic Paraplegia 49, Autosomal Recessive |
| UniProt Protein Details: | |
| NCBI Summary: | The protein encoded by this gene is a member of the tectonin beta-propeller repeat-containing (TECPR) family, and contains both TECPR and tryptophan-aspartic acid repeat (WD repeat) domains. This gene has been implicated in autophagy, as reduced expression levels of this gene have been associated with impaired autophagy. Recessive mutations in this gene have been associated with a hereditary form of spastic paraparesis (HSP). HSP is characterized by progressive spasticity and paralysis of the legs. There is also some evidence linking mutations in this gene with birdshot chorioretinopathy (BSCR), which results in inflammation of the choroid and retina. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Aug 2015] |
| UniProt Code: | O15040 |
| NCBI GenInfo Identifier: | 289547517 |
| NCBI Gene ID: | 9895 |
| NCBI Accession: | NP_001166102.1 |
| UniProt Secondary Accession: | O15040,Q9UEG6, A5PKY3, A6NFY9, A7E2X3, H0YMM9 |
| UniProt Related Accession: | O15040 |
| Molecular Weight: | |
| NCBI Full Name: | tectonin beta-propeller repeat-containing protein 2 isoform 2 |
| NCBI Synonym Full Names: | tectonin beta-propeller repeat containing 2 |
| NCBI Official Symbol: | TECPR2 |
| NCBI Official Synonym Symbols: | SPG49; KIAA0329 |
| NCBI Protein Information: | tectonin beta-propeller repeat-containing protein 2 |
| UniProt Protein Name: | Tectonin beta-propeller repeat-containing protein 2 |
| UniProt Synonym Protein Names: | WD repeat-containing protein KIAA0329/KIAA0297 |
| Protein Family: | Tectonin beta-propeller repeat-containing protein |
| UniProt Gene Name: | TECPR2 |
| UniProt Entry Name: | TCPR2_HUMAN |
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