TECPR1 Antibody (PACO46730)
- SKU:
- PACO46730
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Applications:
- IHC
- Applications:
- IF
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | TECPR1 Antibody (PACO46730) |
| Antibody SKU: | PACO46730 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, IHC, IF |
| Recommended Dilutions: | ELISA:1:2000-1:10000, IHC:1:20-1:200, IF:1:50-1:200 |
| Species Reactivity: | Human |
| Immunogen: | Recombinant Human Tectonin beta-propeller repeat-containing protein 1 protein (199-487AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
| Purification Method: | >95%, Protein G purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Immunohistochemistry of paraffin-embedded human heart tissue using PACO46730 at dilution of 1:100. |
 | Immunofluorescent analysis of A375 cells using PACO46730 at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L). |
| Background: | Tethering factor involved in autophagy. Involved in autophagosome maturation by promoting the autophagosome fusion with lysosomes: acts by associating with both the ATG5-ATG12 conjugate and phosphatidylinositol-3-phosphate (PtdIns(3)P) present at the surface of autophagosomes. Also involved in selective autophagy against bacterial pathogens, by being required for phagophore/preautophagosomal structure biogenesis and maturation. |
| Synonyms: | Tectonin beta-propeller repeat-containing protein 1, TECPR1, KIAA1358 |
| UniProt Protein Function: | TECPR1: Tethering factor involved in autophagy. Involved in autophagosome maturation by promoting the autophagosome fusion with lysosomes: acts by associating with both the ATG5-ATG12 conjugate and phosphatidylinositol-3-phosphate (PtdIns(3)P) present at the surface of autophagosomes. Also involved in selective autophagy against bacterial pathogens, by being required for phagophore/preautophagosomal structure biogenesis and maturation. Interacts with ATG5; the interaction is direct. Interacts with WIPI2. Interacts with the ATG5-ATG12 conjugate, the interaction is however mutually exclusive with ATG16, since it does not interact with ATG12-ATG5-ATG16 complex. Belongs to the TECPR1 family. 4 isoforms of the human protein are produced by alternative splicing.Protein type: Autophagy; Ubiquitin conjugating systemChromosomal Location of Human Ortholog: 7q21.3Cellular Component: lysosomal membraneMolecular Function: phosphatidylinositol 3-phosphate binding; protein bindingBiological Process: autophagy |
| UniProt Protein Details: | |
| NCBI Summary: | This gene encodes a tethering factor involved in autophagy. The encoded protein is found at autolysosomes, and is involved in targeting protein aggregates, damaged mitochondria, and bacterial pathogens for autophagy [provided by RefSeq, Nov 2012] |
| UniProt Code: | Q7Z6L1 |
| NCBI GenInfo Identifier: | 74738829 |
| NCBI Gene ID: | 25851 |
| NCBI Accession: | Q7Z6L1.1 |
| UniProt Secondary Accession: | Q7Z6L1,Q96EB0, Q9P2I9, Q9UFR6, A8KAD1, B3KPZ1, C9J024 F5GX57 |
| UniProt Related Accession: | Q7Z6L1 |
| Molecular Weight: | 129,854 Da |
| NCBI Full Name: | Tectonin beta-propeller repeat-containing protein 1 |
| NCBI Synonym Full Names: | tectonin beta-propeller repeat containing 1 |
| NCBI Official Symbol: | TECPR1 |
| NCBI Official Synonym Symbols: | |
| NCBI Protein Information: | tectonin beta-propeller repeat-containing protein 1 |
| UniProt Protein Name: | Tectonin beta-propeller repeat-containing protein 1 |
| UniProt Synonym Protein Names: | |
| Protein Family: | Tectonin beta-propeller repeat-containing protein |
| UniProt Gene Name: | TECPR1 |
| UniProt Entry Name: | TCPR1_HUMAN |
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