TEAD3 Transcription Factor Activity Assay
- SKU:
- TFAB00175
- Product Type:
- ELISA Kit
- ELISA Type:
- Transcription Factor Assay
- Analytes:
- TEAD3
- Reactivity:
- Human
- Reactivity:
- Mouse
Description
system_update_altDatasheet
| Product Name: | TEAD3 Transcription Factor Activity Assay |
| Product Code: | TFAB00175 |
| Target: | TEAD3 |
| Synonyms: | DTEF-1, TEA domain family member 3, TEAD-3 |
| Reactivity: | Human, Mouse |
| Sample Types: | Nuclear or cell lysates |
The Assay Genie TEAD3 transcription factor activity assay allows for the detection and qualitative analysis of endogenous levels of activated transcription factors in a variety of nuclear and cell lysates
Assay Genie ELISA kits are designed to significantly reduce experiment time and ensure sensitivity and flexibility for high-throughput screening.
| Assay Time: | 4.5 hours |
| Detection Method: | Colorimetric 450 nm |
| Size: | 12 x 8-Well Microstrips |
| Storage: | 4°C for 6 months |
| UniProt Protein Function: | TEAD3: Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Acts by mediating gene expression of YAP1 and WWTR1/TAZ, thereby regulating cell proliferation, migration and epithelial mesenchymal transition (EMT) induction. Binds to multiple functional elements of the human chorionic somatomammotropin-B gene enhancer. |
| UniProt Protein Details: | Protein type:DNA-binding Chromosomal Location of Human Ortholog: 6p21.2 Cellular Component: nucleoplasm Molecular Function:protein binding; transcription factor activity Biological Process: asymmetric neuroblast division; female pregnancy; regulation of transcription from RNA polymerase II promoter; transcription initiation from RNA polymerase II promoter |
| NCBI Summary: | This gene product is a member of the transcriptional enhancer factor (TEF) family of transcription factors, which contain the TEA/ATTS DNA-binding domain. It is predominantly expressed in the placenta and is involved in the transactivation of the chorionic somatomammotropin-B gene enhancer. Translation of this protein is initiated at a non-AUG (AUA) start codon. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q99594 |
| NCBI GenInfo Identifier: | 2501157 |
| NCBI Gene ID: | 7005 |
| NCBI Accession: | Q99594.2 |
| UniProt Secondary Accession: | Q99594,O95910, Q5BJG7, Q8N6Y4, |
| UniProt Related Accession: | Q99594 |
| Molecular Weight: | 48,676 Da |
| NCBI Full Name: | Transcriptional enhancer factor TEF-5 |
| NCBI Synonym Full Names: | TEA domain transcription factor 3 |
| NCBI Official Symbol: | TEAD3 |
| NCBI Official Synonym Symbols: | TEF5; TEAD5; TEF-5; DTEF-1; ETFR-1; TEAD-3 |
| NCBI Protein Information: | transcriptional enhancer factor TEF-5 |
| UniProt Protein Name: | Transcriptional enhancer factor TEF-5 |
| UniProt Synonym Protein Names: | DTEF-1; TEA domain family member 3; TEAD-3 |
| Protein Family: | Transcriptional enhancer factor |
| UniProt Gene Name: | TEAD3 |
| UniProt Entry Name: | TEAD3_HUMAN |
