TDRD12 Antibody (PACO48638)
- SKU:
- PACO48638
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Applications:
- IHC
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | TDRD12 Antibody (PACO48638) |
| Antibody SKU: | PACO48638 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, IHC |
| Recommended Dilutions: | ELISA:1:2000-1:10000, IHC:1:20-1:200 |
| Species Reactivity: | Human |
| Immunogen: | Recombinant Human Putative ATP-dependent RNA helicase TDRD12 protein (991-1164AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
| Purification Method: | >95%, Protein G purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Immunohistochemistry of paraffin-embedded human kidney tissue using PACO48638 at dilution of 1:100. |
| Background: | Probable ATP-binding RNA helicase required during spermatogenesis to repress transposable elements and preventing their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons. Involved in the secondary piRNAs metabolic process. Acts via the PET complex, a multiprotein complex required during the secondary piRNAs metabolic process for the PIWIL2 slicing-triggered loading of PIWIL4 piRNAs. |
| Synonyms: | Putative ATP-dependent RNA helicase TDRD12 (EC 3.6.4.13) (ES cell-associated transcript 8 protein) (Tudor domain-containing protein 12), TDRD12, ECAT8 |
| UniProt Protein Function: | TDRD12: 2 isoforms of the human protein are produced by alternative splicing.Protein type: EC 3.6.4.13Chromosomal Location of Human Ortholog: 19q13.11Molecular Function: nucleic acid binding; helicase activity; ATP bindingBiological Process: fertilization; multicellular organismal development; DNA methylation during gametogenesis; spermatogenesis; RNA-mediated gene silencing; gene expression; male meiosis; cell differentiation |
| UniProt Protein Details: | |
| NCBI Summary: | |
| UniProt Code: | Q587J7 |
| NCBI GenInfo Identifier: | 161016765 |
| NCBI Gene ID: | 91646 |
| NCBI Accession: | NP_001104292.1 |
| UniProt Secondary Accession: | Q587J7 |
| UniProt Related Accession: | Q587J7 |
| Molecular Weight: | 13 kDa (91 aa, 908-999 aa+ NT 6X His Tag) |
| NCBI Full Name: | putative ATP-dependent RNA helicase TDRD12 |
| NCBI Synonym Full Names: | tudor domain containing 12 |
| NCBI Official Symbol: | TDRD12 |
| NCBI Official Synonym Symbols: | ECAT8 |
| NCBI Protein Information: | putative ATP-dependent RNA helicase TDRD12 |
| UniProt Protein Name: | Putative ATP-dependent RNA helicase TDRD12 |
| UniProt Synonym Protein Names: | ES cell-associated transcript 8 protein; Tudor domain-containing protein 12 |
| Protein Family: | Putative ATP-dependent RNA helicase |
| UniProt Gene Name: | TDRD12 |
| UniProt Entry Name: | TDR12_HUMAN |
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