TDP1 Monoclonal Antibody [PAT1F2AT] (CPAB0166)
![TDP1 Monoclonal Antibody [PAT1F2AT] (CPAB0166)](https://cdn11.bigcommerce.com/s-rd6ounxcu2/images/stencil/608x608/products/58392/63574/tdp1-monoclonal-antibody-pat1f2at-cpab0166__59189__34824.1706534995.jpg?c=1 "TDP1 Monoclonal Antibody [PAT1F2AT] (CPAB0166)")
- SKU:
- CPAB0166
- Product Type:
- Antibody
- Antibody Type:
- Monoclonal Antibody
- Reactivity:
- Human
- Host Species:
- Mouse
- Isotype:
- IgG2b
- Clone:
- PAT1F2AT
- Applications:
- WB
- Applications:
- ELISA
![TDP1 Monoclonal Antibody [PAT1F2AT] (CPAB0166)](https://cdn11.bigcommerce.com/s-rd6ounxcu2/images/stencil/1280x1280/products/58392/63574/tdp1-monoclonal-antibody-pat1f2at-cpab0166__59189__34824.1706534995.jpg?c=1&imbypass=on "TDP1 Monoclonal Antibody [PAT1F2AT] (CPAB0166)")
Description
system_update_alt Datasheet
| Product Name: | TDP1 Antibody |
| Product Sku: | CPAB0166 |
| Size: | 5μg |
| Host Species: | Mouse |
| Immunogen: | Anti-human TDP1 mAb, is derived from hybridization of mouse F myeloma cells with spleen cells from BALB/c mice immunized with recombinant human TDP1 amino acids 1-298 purified from Ecoli. |
| Clone: | PAT1F2AT. |
| Reactivity: | Human |
| Applications: | Western Blot, ELISA |
| Purification Method: | TDP1 antibody was purified from mouse ascitic fluids by protein-G affinity chromatography. |
| Isotype: | IgG2b |
| Background: | TDP1 belongs to the phospholipase D family and contains two PLD phosphodiesterase domains. TDP1 is involved in repairing stalled topoisomerase I-DNA complexes by catalyzing the hydrolysis of the phosphodiester bond between the tyrosine residue of topoisomerase I and the 3-prime phosphate of DNA. TDP1 may also remove glycolate from single-stranded DNA containing 3-prime phosphoglycolate, suggesting a role in repair of free-radical mediated DNA double-strand breaks. Mutations in the TDP1 gene are linked to the disease spinocerebellar ataxia with axonal neuropathy (SCAN1). |
| Synonyms: | Tyrosyl-DNA phosphodiesterase 1, Tyr-DNA phosphodiesterase 1, TDP1, FLJ11090, MGC104252. |
| Storage Buffer: | For periods up to 1 month store at 4°C, for longer periods of time, store at -20°C. Prevent freeze thaw cycles. |
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