TCL1 Monoclonal Antibody
- SKU:
- CAB24952
- Product Type:
- Antibody
- Antibody Type:
- Monoclonal Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- WB
- Applications:
- IF
Description
| Product Name: | TCL1 Monoclonal Antibody |
| Product Code: | CAB24952 |
| Reactivity: | Human |
| Applications: | Western blotting, Immunofluorescence |
| Host Species: | Rabbit |
| Purification Method: | Affinity purification |
| Isotype: | IgG |
| Clone No: | ARC64961 |
| Reactivity: | Human |
| Tested Applications: | WB, IF/ICC, ELISA |
| Key Applications: | Western blotting, Immunofluorescence |
| Recommended Dilution: | WB 1:500-1:1000, IF/ICC 1:50-1:200 |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300, 0.05% BSA, 50% glycerol, pH7.3. |
| Positive Samples: | Daudi, Ramos |
| Cellular Location: | Cytoplasm, Endoplasmic reticulum, Microsome, Nucleus |
Overexpression of the TCL1 gene in humans has been implicated in the development of mature T cell leukemia, in which chromosomal rearrangements bring the TCL1 gene in close proximity to the T-cell antigen receptor (TCR)-alpha (MIM 186880) or TCR-beta (MIM 186930) regulatory elements (summarized by Virgilio et al., 1998 [PubMed 9520462]). In normal T cells TCL1 is expressed in CD4-/CD8- cells, but not in cells at later stages of differentiation. TCL1 functions as a coactivator of the cell survival kinase AKT (MIM 164730) (Laine et al., 2000 [PubMed 10983986]).
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-114 of human TCL1 (NP_068801.1). |
| Sequence: | MAECP TLGEA VTDHP DRLWA WEKFV YLDEK QHAWL PLTIE IKDRL QLRVL LRRED VVLGR PMTPT QIGPS LLPIM WQLYP DGRYR SSDSS FWRLV YHIKI DGVED MLLEL LPDD |
| Synonyms: | TCL1 |
| Calculated MW: | 13kDa |
| Observed MW: | 16kDa |
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