TCHP Antibody (PACO41242)
- SKU:
- PACO41242
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Applications:
- IHC
- Applications:
- IF
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | TCHP Antibody (PACO41242) |
| Antibody SKU: | PACO41242 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, IHC, IF |
| Recommended Dilutions: | ELISA:1:2000-1:10000, IHC:1:20-1:200, IF:1:50-1:500 |
| Species Reactivity: | Human |
| Immunogen: | Recombinant Human Trichoplein keratin filament-binding protein (1-498AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
| Purification Method: | >95%, Protein G purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Immunohistochemistry of paraffin-embedded human skin tissue using PACO41242 at dilution of 1:100. |
 | Immunofluorescence staining of MCF-7 cells with PACO41242 at 1:400, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L). |
 | Immunohistochemistry of paraffin-embedded human small intestine tissue using PACO41242 at dilution of 1:100. |
| Background: | Tumor suppressor which has the ability to inhibit cell growth and be pro-apoptotic during cell stress. Inhibits cell growth in bladder and prostate cancer cells by a down-regulation of HSPB1 by inhibiting its phosphorylation. May act as a 'capping' or 'branching' protein for keratin filaments in the cell periphery. May regulate K8/K18 filament and desmosome organization mainly at the apical or peripheral regions of simple epithelial cells. Is a negative regulator of ciliogenesis. |
| Synonyms: | Trichoplein keratin filament-binding protein (Protein TCHP) (Mitochondrial protein with oncostatic activity) (Mitostatin) (Tumor suppressor protein), TCHP |
| UniProt Protein Function: | TCHP: Tumor suppressor which has the ability to inhibit cell growth and be pro-apoptotic during cell stress. Inhibits cell growth in bladder and prostate cancer cells by a down-regulation of HSPB1 by inhibiting its phosphorylation. May act as a 'capping' or 'branching' protein for keratin filaments in the cell periphery. May regulate K8/K18 filament and desmosome organization mainly at the apical or peripheral regions of simple epithelial cells. Belongs to the TCHP family.Protein type: Tumor suppressorChromosomal Location of Human Ortholog: 12q24.11Cellular Component: apical cortex; centrosome; cytoplasm; keratin filament; mitochondrion; plasma membraneMolecular Function: protein bindingBiological Process: apoptosis; negative regulation of cell growth |
| UniProt Protein Details: | |
| NCBI Summary: | |
| UniProt Code: | Q9BT92 |
| NCBI GenInfo Identifier: | 74733103 |
| NCBI Gene ID: | 84260 |
| NCBI Accession: | Q9BT92.1 |
| UniProt Secondary Accession: | Q9BT92,Q8NAG0 |
| UniProt Related Accession: | Q9BT92 |
| Molecular Weight: | 61,072 Da |
| NCBI Full Name: | Trichoplein keratin filament-binding protein |
| NCBI Synonym Full Names: | trichoplein keratin filament binding |
| NCBI Official Symbol: | TCHP |
| NCBI Official Synonym Symbols: | TpMs |
| NCBI Protein Information: | trichoplein keratin filament-binding protein |
| UniProt Protein Name: | Trichoplein keratin filament-binding protein |
| UniProt Synonym Protein Names: | Mitochondrial protein with oncostatic activity; Mitostatin; Tumor suppressor protein |
| Protein Family: | Trichoplein keratin filament-binding protein |
| UniProt Gene Name: | TCHP |
| UniProt Entry Name: | TCHP_HUMAN |
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