TBX3 Transcription Factor Activity Assay
- SKU:
- TFAB00170
- Product Type:
- ELISA Kit
- ELISA Type:
- Transcription Factor Assay
- Analytes:
- TBX3
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
Description
| Product Name: | TBX3 Transcription Factor Activity Assay |
| Product Code: | TFAB00170 |
| Target: | TBX3 |
| Reactivity: | Human, Mouse, Rat |
| Sample Types: | Nuclear or cell lysates |
The Assay Genie TBX3 transcription factor activity assay allows for the detection and qualitative analysis of endogenous levels of activated transcription factors in a variety of nuclear and cell lysates
Assay Genie ELISA kits are designed to significantly reduce experiment time and ensure sensitivity and flexibility for high-throughput screening.
| Assay Time: | 4.5 hours |
| Detection Method: | Colorimetric 450 nm |
| Size: | 12 x 8-Well Microstrips |
| Storage: | 4°C for 6 months |
| UniProt Protein Function: | TBX3: Transcriptional repressor involved in developmental processes. Probably plays a role in limb pattern formation. Defects in TBX3 are the cause of ulnar-mammary syndrome (UMS). UMS is characterized by ulnar ray defects, obesity, hypogenitalism, delayed puberty, hypoplasia of nipples and apocrine glands. 4 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:DNA-binding; Transcription factor Chromosomal Location of Human Ortholog: 12q24.21 Cellular Component: nucleus Molecular Function:protein binding; sequence-specific DNA binding Biological Process: embryonic forelimb morphogenesis; limbic system development; positive regulation of transcription, DNA-dependent; negative regulation of epithelial cell differentiation; palate development; negative regulation of transcription from RNA polymerase II promoter; female genitalia development; forelimb morphogenesis; mammary gland development; determination of anterior/posterior axis, embryo; positive regulation of cell proliferation; male genitalia development; heart looping; skeletal development; luteinizing hormone secretion; blood vessel development; specification of organ position; transcription, DNA-dependent; in utero embryonic development; stem cell maintenance; positive regulation of cell cycle; cell aging; regulation of transcription from RNA polymerase II promoter; organ morphogenesis; mesoderm morphogenesis; follicle-stimulating hormone secretion; embryonic digit morphogenesis; negative regulation of myoblast differentiation; negative regulation of transcription, DNA-dependent; negative regulation of apoptosis Disease: Ulnar-mammary Syndrome |
| NCBI Summary: | This gene is a member of a phylogenetically conserved family of genes that share a common DNA-binding domain, the T-box. T-box genes encode transcription factors involved in the regulation of developmental processes. This protein is a transcriptional repressor and is thought to play a role in the anterior/posterior axis of the tetrapod forelimb. Mutations in this gene cause ulnar-mammary syndrome, affecting limb, apocrine gland, tooth, hair, and genital development. Alternative splicing of this gene results in three transcript variants encoding different isoforms; however, the full length nature of one variant has not been determined. [provided by RefSeq, Jul 2008] |
| UniProt Code: | O15119 |
| NCBI GenInfo Identifier: | 28381401 |
| NCBI Gene ID: | 6926 |
| NCBI Accession: | O15119.4 |
| UniProt Secondary Accession: | O15119,Q8TB20, Q9UKF8, |
| UniProt Related Accession: | O15119 |
| Molecular Weight: | 743 |
| NCBI Full Name: | T-box transcription factor TBX3 |
| NCBI Synonym Full Names: | T-box 3 |
| NCBI Official Symbol: | TBX3 |
| NCBI Official Synonym Symbols: | UMS; XHL; TBX3-ISO |
| NCBI Protein Information: | T-box transcription factor TBX3; T-box protein 3; bladder cancer related protein XHL |
| UniProt Protein Name: | T-box transcription factor TBX3 |
| Protein Family: | T-box transcription factor |
| UniProt Gene Name: | TBX3 |
| UniProt Entry Name: | TBX3_HUMAN |
