TBKBP1 Antibody (PACO62387)
- SKU:
- PACO62387
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Applications:
- IF
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | TBKBP1 Antibody (PACO62387) |
| Antibody SKU: | PACO62387 |
| Size: | 50ul |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, IF |
| Recommended Dilutions: | ELISA:1:2000-1:10000, IF:1:50-1:200 |
| Species Reactivity: | Human |
| Immunogen: | Recombinant Human TANK-binding kinase 1-binding protein 1 protein (327-427AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
| Purification Method: | >95%, Protein G purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Immunofluorescence staining of Hela cells with PACO62387 at 1:100, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L). |
| Background: | Adapter protein which constitutively binds TBK1 and IKBKE playing a role in antiviral innate immunity. |
| Synonyms: | TANK-binding kinase 1-binding protein 1 (TBK1-binding protein 1), TBKBP1, KIAA0775 SINTBAD |
| UniProt Protein Function: | TBKBP1: Adapter protein which constitutively binds TBK1 and IKBKE and may play a role in antiviral innate immunity. Homodimer. May form a heterodimer with NAP1. Interacts with TKB1 and IKBKE. 2 isoforms of the human protein are produced by alternative splicing.Chromosomal Location of Human Ortholog: 17q21.32Molecular Function: protein bindingBiological Process: innate immune response |
| UniProt Protein Details: | |
| NCBI Summary: | TBKBP1 is an adaptor protein that binds to TBK1 (MIM 604834) and is part of the interaction network in the TNF (MIM 191160)/NFKB (see MIM 164011) pathway (Bouwmeester et al., 2004 [PubMed 14743216]).[supplied by OMIM, Mar 2008] |
| UniProt Code: | A7MCY6 |
| NCBI GenInfo Identifier: | 7662302 |
| NCBI Gene ID: | 9755 |
| NCBI Accession: | NP_055541.1 |
| UniProt Secondary Accession: | A7MCY6,O94873, Q14DW3, B2RZG6 |
| UniProt Related Accession: | A7MCY6 |
| Molecular Weight: | 25,043 Da |
| NCBI Full Name: | TANK-binding kinase 1-binding protein 1 |
| NCBI Synonym Full Names: | TBK1 binding protein 1 |
| NCBI Official Symbol: | TBKBP1 |
| NCBI Official Synonym Symbols: | SINTBAD; ProSAPiP2 |
| NCBI Protein Information: | TANK-binding kinase 1-binding protein 1; TBKBP1; TBK1-binding protein 1 |
| UniProt Protein Name: | TANK-binding kinase 1-binding protein 1 |
| UniProt Synonym Protein Names: | |
| Protein Family: | |
| UniProt Gene Name: | TBKBP1 |
| UniProt Entry Name: | TBKB1_HUMAN |
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