TBC1D22A Antibody (PACO17210)
- SKU:
- PACO17210
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Applications:
- IHC
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | TBC1D22A Antibody (PACO17210) |
| Antibody SKU: | PACO17210 |
| Size: | 50ul |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, IHC |
| Recommended Dilutions: | ELISA:1:2000-1:5000, IHC:1:25-1:100 |
| Species Reactivity: | Human, Mouse |
| Immunogen: | Fusion protein of human TBC1D22A |
| Form: | Liquid |
| Storage Buffer: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
| Purification Method: | Antigen affinity purification |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using PACO17210(TBC1D22A Antibody) at dilution 1/25, on the right is treated with fusion protein. (Original magnification: x200). |
| Background: | TBC1D22A (TBC1 domain family, member 22A), also known as C22orf4, is a 517 amino acid, protein that contains one Rab-GAP TBC domain and is thought to function as a GTPase-activating protein for Rab family members. Multiple isoforms of TBC1D22A exist due to alternative splicing events. The gene encoding TBC1D22A maps to human chromosome 22, which houses over 500 genes and is the second smallest human chromosome. Mutations in several of the genes that map to chromosome 22 are involved in the development of Phelan-McDermid syndrome, neurofibromatosis type 2, autism and schizophrenia. Additionally, translocations between chromosomes 9 and 22 may lead to the formation of the Philadelphia chromosome and the subsequent production of the novel fusion protein BCR-Abl, a potent cell proliferation activator found in several types of leukemias. |
| Synonyms: | TBC1 domain family, member 22A |
| UniProt Protein Function: | TBC1D22A: May act as a GTPase-activating protein for Rab family protein(s). 3 isoforms of the human protein are produced by alternative splicing.Protein type: GAPs; GAPs, RabChromosomal Location of Human Ortholog: 22q13.3Cellular Component: endomembrane system; intracellularMolecular Function: GTPase activator activity; protein binding; protein homodimerization activity; Rab GTPase bindingBiological Process: intracellular protein transport; regulation of vesicle fusion |
| UniProt Protein Details: | |
| NCBI Summary: | |
| UniProt Code: | Q8WUA7 |
| NCBI GenInfo Identifier: | 25008319 |
| NCBI Gene ID: | 25771 |
| NCBI Accession: | Q8WUA7.2 |
| UniProt Secondary Accession: | Q8WUA7,Q5TE47, Q6ZUH2, Q92680, Q9BVD6, Q9UGG0, Q9UGT2 Q9UGU6, Q9UH25, B0QYI2 |
| UniProt Related Accession: | Q8WUA7 |
| Molecular Weight: | 53,908 Da |
| NCBI Full Name: | TBC1 domain family member 22A |
| NCBI Synonym Full Names: | TBC1 domain family member 22A |
| NCBI Official Symbol: | TBC1D22A |
| NCBI Official Synonym Symbols: | C22orf4; HSC79E021 |
| NCBI Protein Information: | TBC1 domain family member 22A |
| UniProt Protein Name: | TBC1 domain family member 22A |
| UniProt Synonym Protein Names: | |
| Protein Family: | TBC1 domain family |
| UniProt Gene Name: | TBC1D22A |
| UniProt Entry Name: | TB22A_HUMAN |
| Antibodies |
| TBC1D22A Antibody (PACO12644) |
| Secondary Antibody |
| Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
| Recommended Products |
| Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
| Anti-HRP-conjugated Beta Actin Antibody (CABC028) |
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