TBC1D20 Antibody (PACO39270)
- SKU:
- PACO39270
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Applications:
- WB
- Applications:
- IHC
- Applications:
- IF
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | TBC1D20 Antibody (PACO39270) |
| Antibody SKU: | PACO39270 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB, IHC, IF |
| Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:500-1:5000, IHC:1:20-1:200, IF:1:50-1:200 |
| Species Reactivity: | Human, Mouse |
| Immunogen: | Recombinant Human TBC1 domain family member 20 protein (1-237AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
| Purification Method: | >95%, Protein G purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Western Blot. Positive WB detected in: Mouse brain tissue, Mouse stomach tissue. All lanes: TBC1D20 antibody at 4µg/ml. Secondary. Goat polyclonal to rabbit IgG at 1/50000 dilution. Predicted band size: 46, 20, 49 kDa. Observed band size: 46 kDa. |
 | Immunohistochemistry of paraffin-embedded human adrenal gland tissue using PACO39270 at dilution of 1:100. |
 | Immunohistochemistry of paraffin-embedded human testis tissue using PACO39270 at dilution of 1:100. |
| Background: | GTPase-activating protein specific for Rab1 and Rab2 small GTPase families for which it can accelerate the intrinsic GTP hydrolysis rate by more than five orders of magnitude. |
| Synonyms: | TBC1 domain family member 20, TBC1D20, C20orf140 |
| UniProt Protein Function: | TBC1D20: May act as a GTPase-activating protein for Rab family protein(s). 3 isoforms of the human protein are produced by alternative splicing.Protein type: Membrane protein, integral; GAPs; Membrane protein, multi-pass; GAPs, RabChromosomal Location of Human Ortholog: 20p13Cellular Component: endoplasmic reticulum; endoplasmic reticulum membrane; ER-Golgi intermediate compartment membrane; integral to Golgi membrane; nuclear membraneMolecular Function: GTPase activator activity; protein binding; Rab GTPase bindingBiological Process: COPII coating of Golgi vesicle; ER to Golgi vesicle-mediated transport; Golgi organization and biogenesis; positive regulation of GTPase activity; positive regulation of viral protein levels in host cell; virus assemblyDisease: Warburg Micro Syndrome 4 |
| UniProt Protein Details: | |
| NCBI Summary: | This gene encodes a protein that belongs to a family of GTPase activator proteins of Rab-like small GTPases. The encoded protein and its cognate GTPase, Rab1, bind the nonstructural protein 5A (NS5A) of the hepatitis C virus (HCV) to mediate viral replication. Depletion of this protein inhibits replication of the virus and HCV infection. Mutations in this gene are associated with Warburg micro syndrome 4. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2014] |
| UniProt Code: | Q96BZ9 |
| NCBI GenInfo Identifier: | 34395569 |
| NCBI Gene ID: | 128637 |
| NCBI Accession: | Q96BZ9.1 |
| UniProt Secondary Accession: | Q96BZ9,Q5JWQ7, Q6ZSY8, Q96NE1, Q9BYM7, Q9H140, A8K6I3 B9A6M1 |
| UniProt Related Accession: | Q96BZ9 |
| Molecular Weight: | 48,382 Da |
| NCBI Full Name: | TBC1 domain family member 20 |
| NCBI Synonym Full Names: | TBC1 domain family member 20 |
| NCBI Official Symbol: | TBC1D20 |
| NCBI Official Synonym Symbols: | WARBM4; C20orf140 |
| NCBI Protein Information: | TBC1 domain family member 20 |
| UniProt Protein Name: | TBC1 domain family member 20 |
| UniProt Synonym Protein Names: | |
| Protein Family: | TBC1 domain family |
| UniProt Gene Name: | TBC1D20 |
| UniProt Entry Name: | TBC20_HUMAN |
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