TAF8 Antibody (PACO53870)
- SKU:
- PACO53870
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Applications:
- WB
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | TAF8 Antibody (PACO53870) |
| Antibody SKU: | PACO53870 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB |
| Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:500-1:5000 |
| Species Reactivity: | Human, Mouse, Rat |
| Immunogen: | Recombinant Human Transcription initiation factor TFIID subunit 8 protein (122-311AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
| Purification Method: | >95%, Protein G purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Western Blot. Positive WB detected in: Rat kidney tissue, Mouse liver tissue. All lanes: TAF8 antibody at 2.5µg/ml. Secondary. Goat polyclonal to rabbit IgG at 1/50000 dilution. Predicted band size: 35, 38 kDa. Observed band size: 38 kDa. |
| Background: | Transcription factor TFIID is one of the general factors required for accurate and regulated initiation by RNA polymerase II. Mediates both basal and activator-dependent transcription. Plays a role in the differentiation of preadipocyte fibroblasts to adipocytes, however, does not seem to play a role in differentiation of myoblasts. Required for the integration of TAF10 in the TAF complex. May be important for survival of cells of the inner cell mass which constitute the pluripotent cell population of the early embryo (By similarity). |
| Synonyms: | Transcription initiation factor TFIID subunit 8 (Protein taube nuss) (TBP-associated factor 43 kDa) (TBP-associated factor 8) (Transcription initiation factor TFIID 43 kDa subunit) (TAFII-43) (TAFII43) (hTAFII43), TAF8, TAFII43 TBN |
| UniProt Protein Function: | TBN: Transcription factor TFIID is one of the general factors required for accurate and regulated initiation by RNA polymerase II. Mediates both basal and activator-dependent transcription. Plays a role in the differentiation of preadipocyte fibroblasts to adipocytes, however, does not seem to play a role in differentiation of myoblasts. Required for the integration of TAF10 in the TAF complex. May be important for survival of cells of the inner cell mass which constitute the pluripotent cell population of the early embryo. Belongs to the TAF8 family. 3 isoforms of the human protein are produced by alternative splicing.Chromosomal Location of Human Ortholog: 6p21.1Cellular Component: nucleoplasm; nucleus; perinuclear region of cytoplasm; transcription factor TFIID complexMolecular Function: protein bindingBiological Process: maintenance of protein localization in nucleus; positive regulation of transcription, DNA-dependent; regulation of fat cell differentiation; snRNA transcription from RNA polymerase II promoter |
| UniProt Protein Details: | |
| NCBI Summary: | This gene encodes one of several TATA-binding protein (TBP)-associated factors (TAFs), which are integral subunits of the general transcription factor complex TFIID. TFIID recognizes the core promoter of many genes and nucleates the assembly of a transcription preinitiation complex containing RNA polymerase II and other initiation factors. The protein encoded by this gene contains an H4-like histone fold domain, and interacts with several subunits of TFIID including TBP and the histone-fold protein TAF10. Alternatively spliced transcript variants have been described, but their biological validity has not been determined. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q7Z7C8 |
| NCBI GenInfo Identifier: | 74723384 |
| NCBI Gene ID: | 129685 |
| NCBI Accession: | Q7Z7C8.1 |
| UniProt Secondary Accession: | Q7Z7C8,Q5T0K1, Q8N4R9, Q96M52 |
| UniProt Related Accession: | Q7Z7C8 |
| Molecular Weight: | 37,411 Da |
| NCBI Full Name: | Transcription initiation factor TFIID subunit 8 |
| NCBI Synonym Full Names: | TATA-box binding protein associated factor 8 |
| NCBI Official Symbol: | TAF8 |
| NCBI Official Synonym Symbols: | II; TAF; TBN; TAFII43; TAFII-43 |
| NCBI Protein Information: | transcription initiation factor TFIID subunit 8 |
| UniProt Protein Name: | Transcription initiation factor TFIID subunit 8 |
| UniProt Synonym Protein Names: | Protein taube nuss; TBP-associated factor 43 kDa; TBP-associated factor 8; Transcription initiation factor TFIID 43 kDa subunit; TAFII-43; TAFII43; hTAFII43 |
| Protein Family: | Transcription initiation factor |
| UniProt Gene Name: | TAF8 |
| UniProt Entry Name: | TAF8_HUMAN |
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