TAF4 Antibody (PACO21673)
- SKU:
- PACO21673
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Applications:
- WB
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | TAF4 Antibody (PACO21673) |
| Antibody SKU: | PACO21673 |
| Size: | 100ul |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB |
| Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:500-1:3000 |
| Species Reactivity: | Human |
| Immunogen: | Synthesized peptide derived from internal of human TAF4. |
| Form: | Liquid |
| Storage Buffer: | Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Purification Method: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Western blot analysis of extracts from NIH-3T3 cells, using TAF4 antibody. |
| Background: | Part of the TFIID complex, a multimeric protein complex that plays a central role in mediating promoter responses to various activators and repressors. Potentiates transcriptional activation by the AF-2S of the retinoic acid, vitamin D3 and thyroid hormone. Deloukas P., Nature 414:865-871(2001). |
| Synonyms: | Transcription initiation factor TFIID subunit 4; TBP-associated factor 4; Transcription initiation factor TFIID 135 kDa subunit; TAF(II)135; TAFII-135 |
| UniProt Protein Function: | TAF4: Makes part of TFIID is a multimeric protein complex that plays a central role in mediating promoter responses to various activators and repressors. Potentiates transcriptional activation by the AF-2S of the retinoic acid, vitamin D3 and thyroid hormone. Belongs to the TAF4 family. |
| UniProt Protein Details: | Protein type:Transcription factor Chromosomal Location of Human Ortholog: 20q13.33 Cellular Component: cytoplasm; nucleoplasm; transcription factor TFIID complex Molecular Function:DNA binding; protein binding; transcription coactivator activity; transcription factor activity Biological Process: positive regulation of transcription, DNA-dependent; RNA elongation from RNA polymerase II promoter; transcription from RNA polymerase II promoter; transcription initiation; transcription initiation from RNA polymerase II promoter |
| NCBI Summary: | Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that coordinates these activities is transcription factor IID (TFIID), which binds to the core promoter to position the polymerase properly, serves as the scaffold for assembly of the remainder of the transcription complex, and acts as a channel for regulatory signals. TFIID is composed of the TATA-binding protein (TBP) and a group of evolutionarily conserved proteins known as TBP-associated factors or TAFs. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors (GTFs) to facilitate complex assembly and transcription initiation. This gene encodes one of the larger subunits of TFIID that has been shown to potentiate transcriptional activation by retinoic acid, thyroid hormone and vitamin D3 receptors. In addition, this subunit interacts with the transcription factor CREB, which has a glutamine-rich activation domain, and binds to other proteins containing glutamine-rich regions. Aberrant binding to this subunit by proteins with expanded polyglutamine regions has been suggested as one of the pathogenetic mechanisms underlying a group of neurodegenerative disorders referred to as polyglutamine diseases. [provided by RefSeq, Jul 2008] |
| UniProt Code: | O00268 |
| NCBI GenInfo Identifier: | 56405299 |
| NCBI Gene ID: | 6874 |
| NCBI Accession: | O00268.2 |
| UniProt Secondary Accession: | O00268,Q5TBP6, Q99721, Q9BR40, Q9BX42, A6NGD9, |
| UniProt Related Accession: | O00268 |
| Molecular Weight: | 110114 Da |
| NCBI Full Name: | Transcription initiation factor TFIID subunit 4 |
| NCBI Synonym Full Names: | TATA-box binding protein associated factor 4 |
| NCBI Official Symbol: | TAF4 |
| NCBI Official Synonym Symbols: | TAF2C; TAF4A; TAF2C1; TAFII130; TAFII135 |
| NCBI Protein Information: | transcription initiation factor TFIID subunit 4 |
| UniProt Protein Name: | Transcription initiation factor TFIID subunit 4 |
| UniProt Synonym Protein Names: | RNA polymerase II TBP-associated factor subunit C; TBP-associated factor 4; Transcription initiation factor TFIID 130 kDa subunit; TAF(II)130; TAFII-130; TAFII130; Transcription initiation factor TFIID 135 kDa subunit; TAF(II)135; TAFII-135; TAFII135 |
| Protein Family: | Transcription initiation factor |
| UniProt Gene Name: | TAF4 |
| UniProt Entry Name: | TAF4_HUMAN |
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