Antibody Name:	TACC2 Antibody (PACO20648)
Antibody SKU:	PACO20648
Size:	50ul
Host Species:	Rabbit
Tested Applications:	ELISA, WB, IHC
Recommended Dilutions:	ELISA:1:1000-1:2000, WB:1:200-1:1000, IHC:1:25-1:100
Species Reactivity:	Human, Mouse
Immunogen:	Synthetic peptide of human TACC2

Form:	Liquid
Storage Buffer:	-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method:	Antigen affinity purification
Clonality:	Polyclonal
Isotype:	IgG
Conjugate:	Non-conjugated

	The image on the left is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using PACO20648(TACC2 Antibody) at dilution 1/30, on the right is treated with synthetic peptide. (Original magnification: x200).
	Gel: 6%SDS-PAGE, Lysate: 40 µg, Lane: Mouse muscle tissue, Primary antibody: PACO20648(TACC2 Antibody) at dilution 1/300, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 5 minutes.
	The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using PACO20648(TACC2 Antibody) at dilution 1/30, on the right is treated with synthetic peptide. (Original magnification: x200).

Background:

Transforming acid, c coiled-coil proteins are a conserved family of centrosome- and microtubule-interacting proteins that are implicated in cancer. This gene encodes a protein that concentrates at centrosomes throughout the cell cycle. This gene lies within a chromosomal region associated with tumorigenesis. Expression of this gene is induced by erythropoietin and is thought to affect the progression of breast tumors. Several transcript variants encoding different isoforms have been found for this gene.

Synonyms:

transforming, acid, c coiled-coil containing protein 2

UniProt Protein Function:	TACC2: Plays a role in the microtubule-dependent coupling of the nucleus and the centrosome. Involved in the processes that regulate centrosome-mediated interkinetic nuclear migration (INM) of neural progenitors. May play a role in organizing centrosomal microtubules. May act as a tumor suppressor protein. May represent a tumor progression marker. Belongs to the TACC family. 6 isoforms of the human protein are produced by alternative splicing.Protein type: Cell cycle regulationChromosomal Location of Human Ortholog: 10q26Cellular Component: microtubule cytoskeleton; nucleoplasm; cytoplasm; nucleolus; microtubule organizing center; nucleusMolecular Function: protein domain specific binding; nuclear hormone receptor bindingBiological Process: cell proliferation; regulation of microtubule-based process; astral microtubule organization and biogenesis; neurogenesis; cerebral cortex development; microtubule cytoskeleton organization and biogenesis; interkinetic nuclear migration
UniProt Protein Details:
NCBI Summary:	Transforming acidic coiled-coil proteins are a conserved family of centrosome- and microtubule-interacting proteins that are implicated in cancer. This gene encodes a protein that concentrates at centrosomes throughout the cell cycle. This gene lies within a chromosomal region associated with tumorigenesis. Expression of this gene is induced by erythropoietin and is thought to affect the progression of breast tumors. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
UniProt Code:	O95359
NCBI GenInfo Identifier:	122066295
NCBI Gene ID:	10579
NCBI Accession:	O95359.3
UniProt Secondary Accession:	O95359,Q4VXL0, Q4VXL3, Q4VXL6, Q4VXL7, Q5U5T7, Q86WG6 Q86WG7, Q8TCK9, Q9BVQ1
UniProt Related Accession:	O95359
Molecular Weight:	2948
NCBI Full Name:	Transforming acidic coiled-coil-containing protein 2
NCBI Synonym Full Names:	transforming, acidic coiled-coil containing protein 2
NCBI Official Symbol:	TACC2
NCBI Official Synonym Symbols:	AZU-1; ECTACC
NCBI Protein Information:	transforming acidic coiled-coil-containing protein 2; anti zuai-1
UniProt Protein Name:	Transforming acidic coiled-coil-containing protein 2
UniProt Synonym Protein Names:	Anti-Zuai-1; AZU-1
Protein Family:	Transforming acidic coiled-coil-containing protein
UniProt Gene Name:	TACC2
UniProt Entry Name:	TACC2_HUMAN