SYT2 Antibody (PACO18437)
- SKU:
- PACO18437
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Applications:
- WB
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | SYT2 Antibody (PACO18437) |
| Antibody SKU: | PACO18437 |
| Size: | 50ul |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB |
| Recommended Dilutions: | ELISA:1:2000-1:5000, WB:1:500-1:2000 |
| Species Reactivity: | Human, Mouse, Rat |
| Immunogen: | Synthetic peptide of human SYT2 |
| Form: | Liquid |
| Storage Buffer: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
| Purification Method: | Antigen affinity purification |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Gel: 10%SDS-PAGE, Lysate: 50 μg, Lane 1-2: Human fetal brain tissue, Human lung tissue, Primary antibody: PACO18437(SYT2 Antibody) at dilution 1/700, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 40 seconds. |
| Background: | Synaptotagmin-2 is a protein that in humans is encoded by the SYT2 gene. Synaptotagmins, like SYT2, are integral membrane proteins of synaptic vesicles thought to serve as Ca(2+) sensors in the process of vesicular trafficking and exocytosis. May have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse. It binds acid, c phospholipids with a specificity that requires the presence of both an acid, c head group and a diacyl backbone. |
| Synonyms: | synaptotagmin II |
| UniProt Protein Function: | SYT2: May have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse. It binds acidic phospholipids with a specificity that requires the presence of both an acidic head group and a diacyl backbone. Belongs to the synaptotagmin family. |
| UniProt Protein Details: | Protein type:Membrane protein, integral; Lipid-binding; Vesicle; Calcium-binding Chromosomal Location of Human Ortholog: 1q32.1 Cellular Component: intracellular membrane-bound organelle; synaptic vesicle membrane; plasma membrane; integral to membrane; cell junction Molecular Function:protein binding; calcium-dependent phospholipid binding; transporter activity; calcium ion binding Biological Process: transport; pathogenesis Disease: Myasthenic Syndrome, Presynaptic, Congenital, With Or Without Motor Neuropathy |
| NCBI Summary: | This gene encodes a synaptic vesicle membrane protein. The encoded protein is thought to function as a calcium sensor in vesicular trafficking and exocytosis. Mutations in this gene are associated with myasthenic syndrome, presynaptic, congenital, with or without motor neuropathy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2014] |
| UniProt Code: | Q8N9I0 |
| NCBI GenInfo Identifier: | 116242811 |
| NCBI Gene ID: | 127833 |
| NCBI Accession: | Q8N9I0.2 |
| UniProt Secondary Accession: | Q8N9I0,Q496K5, Q8NBE5, |
| UniProt Related Accession: | Q8N9I0 |
| Molecular Weight: | 419 |
| NCBI Full Name: | Synaptotagmin-2 |
| NCBI Synonym Full Names: | synaptotagmin II |
| NCBI Official Symbol: | SYT2 |
| NCBI Official Synonym Symbols: | MYSPC; SytII |
| NCBI Protein Information: | synaptotagmin-2 |
| UniProt Protein Name: | Synaptotagmin-2 |
| UniProt Synonym Protein Names: | Synaptotagmin II; SytII |
| Protein Family: | Synaptotagmin |
| UniProt Gene Name: | SYT2 |
| UniProt Entry Name: | SYT2_HUMAN |
