α-Synuclein Monoclonal Antibody (CAB24951)

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SKU:
CAB24951
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Applications:
WB
Applications:
IF

Description

Product Name:α-Synuclein Monoclonal Antibody
Product Code:CAB24951
Reactivity:Human, Mouse, Rat
Applications:Western blotting, Immunofluorescence
Host Species:Rabbit
Purification Method:Affinity purification
Isotype:IgG
Clone No:ARC64510
Reactivity:Human, Mouse, Rat
Tested Applications:WB, IF/ICC, ELISA
Key Applications:Western blotting, Immunofluorescence
Recommended Dilution:WB 1:1000-1:5000, IF/ICC 1:50-1:200
Storage Buffer:Store at -20°C. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300, 0.05% BSA, 50% glycerol, pH7.3.
Positive Samples:HEL
Cellular Location:Cell junction, Cytoplasm, Membrane, Nucleus, Secreted, cytosol, synapse, Cell projection, axon

Alpha-synuclein is a member of the synuclein family, which also includes beta- and gamma-synuclein. Synucleins are abundantly expressed in the brain and alpha- and beta-synuclein inhibit phospholipase D2 selectively. SNCA may serve to integrate presynaptic signaling and membrane trafficking. Defects in SNCA have been implicated in the pathogenesis of Parkinson disease. SNCA peptides are a major component of amyloid plaques in the brains of patients with Alzheimer's disease. Alternatively spliced transcripts encoding different isoforms have been identified for this gene.

Immunogen:Recombinant fusion protein containing a sequence corresponding to aminoacids 1-140 of human α-Synuclein(NP_000336.1).
Sequence:MDVFM KGLSK AKEGV VAAAE KTKQG VAEAA GKTKE GVLYV GSKTK EGVVH GVATV AEKTK EQVTN VGGAV VTGVT AVAQK TVEGA GSIAA ATGFV KKDQL GKNEE GAPQE GILED MPVDP DNEAY EMPSE EGYQD YEPEA
Synonyms:PD1, NACP, PARK1, PARK4
Calculated MW:14kDa
Observed MW:18KDa
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