α-Synuclein Monoclonal Antibody (CAB24950)
- SKU:
- CAB24950
- Product Type:
- Antibody
- Antibody Type:
- Monoclonal Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- WB
- Applications:
- IHC
- Applications:
- IF
Description
| Product Name: | α-Synuclein Monoclonal Antibody |
| Product Code: | CAB24950 |
| Reactivity: | Human, Mouse, Rat |
| Applications: | Western blotting, Immunohistochemistry, Immunofluorescence |
| Host Species: | Rabbit |
| Purification Method: | Affinity purification |
| Isotype: | IgG |
| Clone No: | ARC64511 |
| Reactivity: | Human, Mouse, Rat |
| Tested Applications: | WB, IHC-P, IF/ICC, ELISA |
| Key Applications: | Western blotting, Immunohistochemistry, Immunofluorescence |
| Recommended Dilution: | WB 1:500-1:1000, IHC-P 1:50-1:200, IF/ICC 1:50-1:200 |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300, 0.05% BSA, 50% glycerol, pH7.3. |
| Positive Samples: | HEL |
| Cellular Location: | Cell junction, Cytoplasm, Membrane, Nucleus, Secreted, cytosol, synapse, Cell projection, axon |
Alpha-synuclein is a member of the synuclein family, which also includes beta- and gamma-synuclein. Synucleins are abundantly expressed in the brain and alpha- and beta-synuclein inhibit phospholipase D2 selectively. SNCA may serve to integrate presynaptic signaling and membrane trafficking. Defects in SNCA have been implicated in the pathogenesis of Parkinson disease. SNCA peptides are a major component of amyloid plaques in the brains of patients with Alzheimer's disease. Alternatively spliced transcripts encoding different isoforms have been identified for this gene.
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to aminoacids 1-140 of human α-Synuclein(NP_000336.1). |
| Sequence: | MDVFM KGLSK AKEGV VAAAE KTKQG VAEAA GKTKE GVLYV GSKTK EGVVH GVATV AEKTK EQVTN VGGAV VTGVT AVAQK TVEGA GSIAA ATGFV KKDQL GKNEE GAPQE GILED MPVDP DNEAY EMPSE EGYQD YEPEA |
| Synonyms: | PD1, NACP, PARK1, PARK4 |
| Calculated MW: | 14kDa |
| Observed MW: | 18kDa |
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