Synpr Antibody (PACO21458)
- SKU:
- PACO21458
- Product Type:
- Antibody
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Applications:
- WB
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | Synpr Antibody (PACO21458) |
| Antibody SKU: | PACO21458 |
| Size: | 100ul |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB |
| Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:500-1:1000 |
| Species Reactivity: | Mouse, Rat |
| Immunogen: | Peptide sequence around aa.257~261(G-P-T-S-F)derived from Rat synaptophysin 2. |
| Form: | Liquid |
| Storage Buffer: | Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Purification Method: | Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide. |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Western blot analysis of extract from rat brain and mouse brain using synaptophysin 2 Antibody. |
| Background: | Synaptophysin (SYP) is a neuronal synaptic vesicle glycoprotein that is expressed in neuroendocrine cells and neoplasms, and thus can be used as a marker in tumor diagnosis (1). Synaptophysin contains four transmembrane domains that form a hexameric channel or gap junction-like pore (2). Synaptophysin binds to the SNARE protein synaptobrevin/VAMP, which prevents the inclusion of synaptobrevin in the synaptic vesicle fusion complex and creates a pool of synaptobrevin for exocytosis when synapse activity increases (3). Synaptophysin is also responsible for targeting synaptobrevin 2/VAMP2 to synaptic vesicles, a critical component of the fusion complex (4). |
| Synonyms: | Synpr |
| UniProt Protein Function: | SYNPR: Intrinsic membrane protein of small synaptic vesicles. Probable vesicular channel protein. Belongs to the synaptophysin/synaptobrevin family.Protein type: Membrane protein, multi-pass; Membrane protein, integralCellular Component: neuron projection; synaptic vesicle membrane; cell junction; integral to synaptic vesicle membraneMolecular Function: transporter activityBiological Process: transport |
| UniProt Protein Details: | |
| NCBI Summary: | synaptic vesicle membrane protein; member of the synaptophysin family [RGD, Feb 2006] |
| UniProt Code: | P22831 |
| NCBI GenInfo Identifier: | 13027428 |
| NCBI Gene ID: | 66030 |
| NCBI Accession: | NP_076464.1 |
| UniProt Secondary Accession: | P22831,Q9ERH1 |
| UniProt Related Accession: | P22831 |
| Molecular Weight: | 29,107 Da |
| NCBI Full Name: | synaptoporin |
| NCBI Synonym Full Names: | synaptoporin |
| NCBI Official Symbol: | Synpr |
| NCBI Official Synonym Symbols: | |
| NCBI Protein Information: | synaptoporin |
| UniProt Protein Name: | Synaptoporin |
| UniProt Synonym Protein Names: | |
| Protein Family: | Synaptoporin |
| UniProt Gene Name: | Synpr |
| UniProt Entry Name: | SYNPR_RAT |
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