SYNM Antibody (PACO53742)
- SKU:
- PACO53742
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Applications:
- IHC
- Applications:
- IF
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | SYNM Antibody (PACO53742) |
| Antibody SKU: | PACO53742 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, IHC, IF |
| Recommended Dilutions: | ELISA:1:2000-1:10000, IHC:1:20-1:200, IF:1:50-1:200 |
| Species Reactivity: | Human |
| Immunogen: | Recombinant Human Synemin protein (1147-1417AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
| Purification Method: | >95%, Protein G purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Immunohistochemistry of paraffin-embedded human skeletal muscle tissue using PACO53742 at dilution of 1:100. |
 | Immunofluorescent analysis of Hela cells using PACO53742 at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L). |
| Background: | Type-VI intermediate filament (IF) which plays an important cytoskeletal role within the muscle cell cytoskeleton. It forms heteropolymeric IFs with desmin and/or vimentin, and via its interaction with cytoskeletal proteins alpha-dystrobrevin, dystrophin, talin-1, utrophin and vinculin, is able to link these heteropolymeric IFs to adherens-type junctions, such as to the costameres, neuromuscular junctions, and myotendinous junctions within striated muscle cells. |
| Synonyms: | Synemin (Desmuslin), SYNM, DMN KIAA0353 SYN |
| UniProt Protein Function: | DMN: Type-VI intermediate filament (IF) which plays an important cytoskeletal role within the muscle cell cytoskeleton. It forms heteropolymeric IFs with desmin and/or vimentin, and via its interaction with cytoskeletal proteins alpha-dystrobrevin, dystrophin, talin-1, utrophin and vinculin, is able to link these heteropolymeric IFs to adherens-type junctions, such as to the costameres, neuromuscular junctions, and myotendinous junctions within striated muscle cells. Belongs to the intermediate filament family. 3 isoforms of the human protein are produced by alternative splicing.Protein type: Motility/polarity/chemotaxisChromosomal Location of Human Ortholog: 15q26.3Cellular Component: adherens junction; costamere; intermediate filament; membrane; neurofilament cytoskeletonMolecular Function: intermediate filament binding; protein binding; structural constituent of cytoskeleton; structural constituent of muscle; vinculin bindingBiological Process: intermediate filament cytoskeleton organization and biogenesis |
| UniProt Protein Details: | |
| NCBI Summary: | The protein encoded by this gene is an intermediate filament (IF) family member. IF proteins are cytoskeletal proteins that confer resistance to mechanical stress and are encoded by a dispersed multigene family. This protein has been found to form a linkage between desmin, which is a subunit of the IF network, and the extracellular matrix, and provides an important structural support in muscle. Two alternatively spliced variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008] |
| UniProt Code: | O15061 |
| NCBI GenInfo Identifier: | 20137613 |
| NCBI Gene ID: | 23336 |
| NCBI Accession: | O15061.2 |
| UniProt Secondary Accession: | O15061,Q2TBJ4, Q5NJJ9, Q8TE61, Q8TE62, A7E2Y2 |
| UniProt Related Accession: | O15061 |
| Molecular Weight: | 39,042 Da |
| NCBI Full Name: | Synemin |
| NCBI Synonym Full Names: | synemin |
| NCBI Official Symbol: | SYNM |
| NCBI Official Synonym Symbols: | DMN; SYN |
| NCBI Protein Information: | synemin |
| UniProt Protein Name: | Synemin |
| UniProt Synonym Protein Names: | Desmuslin |
| Protein Family: | |
| UniProt Gene Name: | SYNM |
| UniProt Entry Name: | SYNEM_HUMAN |
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