SYNE4 Antibody (PACO39390)
- SKU:
- PACO39390
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | SYNE4 Antibody (PACO39390) |
| Antibody SKU: | PACO39390 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA |
| Recommended Dilutions: | |
| Species Reactivity: | Human |
| Immunogen: | Recombinant Human Nesprin-4 protein (1-242AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
| Purification Method: | >95%, Protein G purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
| Background: | As a component of the LINC (LInker of Nucleoskeleton and Cytoskeleton) complex, involved in the connection between the nuclear lamina and the cytoskeleton. The nucleocytoplasmic interactions established by the LINC complex play an important role in the transmission of mechanical forces across the nuclear envelope and in nuclear movement and positioning. Behaves as a kinesin cargo, providing a functional binding site for kinesin-1 at the nuclear envelope. Hence may contribute to the establishment of secretory epithelial morphology by promoting kinesin-dependent apical migration of the centrosome and Golgi apparatus and basal localization of the nucleus. |
| Synonyms: | Nesprin-4 (KASH domain-containing protein 4) (KASH4) (Nuclear envelope spectrin repeat protein 4), SYNE4, C19orf46 |
| UniProt Protein Function: | |
| UniProt Protein Details: | |
| NCBI Summary: | This gene is a member of the nesprin family of genes, that encode KASH (Klarsicht, Anc-1, Syne Homology) domain-containing proteins. In addition to the KASH domain, this protein also contains a coiled-coil and leucine zipper region, a spectrin repeat, and a kinesin-1 binding region. This protein localizes to the outer nuclear membrane, and is part of the linker of nucleoskeleton and cytoskeleton (LINC) complex in the nuclear envelope. LINC complexes are formed by SUN (Sad1, UNC-84)-KASH pairs, and are thought to mechanically couple nuclear components to the cytoskeleton. Mutations in this gene have been associated with progressive high-frequency hearing loss. The absence of this protein in mice also caused hearing loss, and changes in hair cell morphology in the ears. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Aug 2015] |
| UniProt Code: | Q8N205 |
| NCBI GenInfo Identifier: | 89886475 |
| NCBI Gene ID: | 163183 |
| NCBI Accession: | NP_001034965.1 |
| UniProt Secondary Accession: | Q8N205 |
| UniProt Related Accession: | Q8N205 |
| Molecular Weight: | 32kDa |
| NCBI Full Name: | nesprin-4 isoform 1 |
| NCBI Synonym Full Names: | spectrin repeat containing nuclear envelope family member 4 |
| NCBI Official Symbol: | SYNE4 |
| NCBI Official Synonym Symbols: | KASH4; Nesp4; DFNB76; C19orf46 |
| NCBI Protein Information: | nesprin-4 |
| UniProt Protein Name: | Nesprin-4 |
| UniProt Synonym Protein Names: | Nuclear envelope spectrin repeat protein 4 |
| Protein Family: | Nesprin |
| UniProt Gene Name: | SYNE4 |
| UniProt Entry Name: | SYNE4_HUMAN |
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