SUSD6 Antibody (PACO38390)
- SKU:
- PACO38390
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Applications:
- IHC
- Applications:
- IF
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | SUSD6 Antibody (PACO38390) |
| Antibody SKU: | PACO38390 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, IHC, IF |
| Recommended Dilutions: | ELISA:1:2000-1:10000, IHC:1:20-1:200, IF:1:50-1:200 |
| Species Reactivity: | Human |
| Immunogen: | Recombinant Human Sushi domain-containing protein 6 protein (144-303AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
| Purification Method: | >95%, Protein G purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Immunohistochemistry of paraffin-embedded human kidney tissue using PACO38390 at dilution of 1:100. |
 | Immunofluorescent analysis of MCF-7 cells using PACO38390 at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L). |
| Background: | May play a role in growth-suppressive activity and cell death. May be involved in the production of chemokine molecules in umbilical vein endothelial cells (HUVECs) cultured in THP1 monocyte LPS-induced medium. Plays a role in preventing tumor onset. |
| Synonyms: | Sushi domain-containing protein 6 (Drug-activated gene overexpressed protein), SUSD6, DRAGO KIAA0247 |
| UniProt Protein Function: | SUSD6: May play a role in growth-suppressive activity and cell death (PubMed:24652652). May be involved in the production of chemokine molecules in umbilical vein endothelial cells (HUVECs) cultured in THP1 monocyte LPS-induced medium (PubMed:20236627). Plays a role in preventing tumor onset. {ECO:0000250|UniProtKB:Q8BGE4, ECO:0000269|PubMed:20236627, ECO:0000269|PubMed:24652652}. Up-regulated by chemotherapeutic DNA-damaging agents and by p53/TP53 and/or by p73/TP73 in response to cytotoxic insults (PubMed:24652652). Up-regulated by lipopolysaccharide (LPS) in monocytic THP1 cells (PubMed:20236627). Up-regulated in umbilical vein endothelial cells (HUVECs) cultured in THP1 monocyte LPS-induced medium. {ECO:0000269|PubMed:20236627, ECO:0000269|PubMed:24652652}Protein type: Membrane protein, integral; Tumor suppressorChromosomal Location of Human Ortholog: 14q24.1Cellular Component: integral to membraneMolecular Function: protein bindingBiological Process: cell death; response to DNA damage stimulus |
| UniProt Protein Details: | |
| NCBI Summary: | |
| UniProt Code: | Q92537 |
| NCBI GenInfo Identifier: | 7662020 |
| NCBI Gene ID: | 9766 |
| NCBI Accession: | NP_055549.1 |
| UniProt Secondary Accession: | Q92537 |
| UniProt Related Accession: | Q92537 |
| Molecular Weight: | 32,090 Da |
| NCBI Full Name: | sushi domain-containing protein 6 |
| NCBI Synonym Full Names: | sushi domain containing 6 |
| NCBI Official Symbol: | SUSD6 |
| NCBI Official Synonym Symbols: | DRAGO; KIAA0247 |
| NCBI Protein Information: | sushi domain-containing protein 6 |
| UniProt Protein Name: | Sushi domain-containing protein 6 |
| UniProt Synonym Protein Names: | Drug-activated gene overexpressed protein |
| Protein Family: | Sushi domain-containing protein |
| UniProt Gene Name: | SUSD6 |
| UniProt Entry Name: | SUSD6_HUMAN |
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