STT3A Antibody (PACO30190)
- SKU:
- PACO30190
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Applications:
- IHC
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | STT3A Antibody (PACO30190) |
| Antibody SKU: | PACO30190 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, IHC |
| Recommended Dilutions: | ELISA:1:2000-1:10000, IHC:1:20-1:200 |
| Species Reactivity: | Human |
| Immunogen: | Recombinant Human Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3A protein (39-114AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
| Purification Method: | >95%, Protein G purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Immunohistochemistry of paraffin-embedded human pancreatic cancer using PACO30190 at dilution of 1:100. |
| Background: | Catalytic subunit of the N-oligosaccharyl transferase (OST) complex which catalyzes the transfer of a high mannose oligosaccharide from a lipid-linked oligosaccharide donor to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). SST3A seems to be involved in complex substrate specificity. STT3A is present in the majority of OST complexes and mediates cotranslational N-glycosylation of most sites on target proteins, while STT3B-containing complexes are required for efficient cotranslational glycosylation and mediate glycosylation of sites that have been skipped by STT3A. |
| Synonyms: | Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3A (Oligosaccharyl transferase subunit STT3A) (STT3-A) (EC 2.4.99.18) (B5) (Integral membrane protein 1) (Transmembrane protein TMC), STT3A, ITM1 TMC |
| UniProt Protein Function: | ITM1: Catalytic component of oligosaccharyltransferase (OST) oligosaccharyltransferase (OST) complex which catalyzes the transfer of a high mannose oligosaccharide from a lipid-linked oligosaccharide donor to an asparagine residue within an Asn-X- Ser/Thr consensus motif in nascent polypeptide chains. N- glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). SST3A seems to be involved in complex substrate specificity. STT3A is present in the majority of OST complexes and mediates cotranslational N-glycosylation of most sites on target proteins, while STT3B-containing complexes are required for efficient cotranslational glycosylation and mediate glycosylation of sites that have been skipped by STT3A. Belongs to the STT3 family.Protein type: Membrane protein, multi-pass; EC 2.4.99.18; Membrane protein, integral; Endoplasmic reticulum; TransferaseChromosomal Location of Human Ortholog: 11q23.3Cellular Component: endoplasmic reticulum membrane; membrane; oligosaccharyl transferase complexMolecular Function: dolichyl-diphosphooligosaccharide-protein glycotransferase activity; protein bindingBiological Process: co-translational protein modification; post-translational protein modification; protein amino acid N-linked glycosylation via asparagineDisease: Congenital Disorder Of Glycosylation, Type Iw |
| UniProt Protein Details: | |
| NCBI Summary: | The protein encoded by this gene is a catalytic subunit of the N-oligosaccharyltransferase (OST) complex, which functions in the endoplasmic reticulum to transfer glycan chains to asparagine residues of target proteins. A separate complex containing a similar catalytic subunit with an overlapping function also exists. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2015] |
| UniProt Code: | P46977 |
| NCBI GenInfo Identifier: | 182676409 |
| NCBI Gene ID: | 3703 |
| NCBI Accession: | P46977.2 |
| UniProt Secondary Accession: | P46977,Q86XU9, Q8TE35, Q8WUB4, B4DJ24, E9PNQ1 |
| UniProt Related Accession: | P46977 |
| Molecular Weight: | 80530 Da |
| NCBI Full Name: | Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3A |
| NCBI Synonym Full Names: | STT3A, catalytic subunit of the oligosaccharyltransferase complex |
| NCBI Official Symbol: | STT3A |
| NCBI Official Synonym Symbols: | TMC; ITM1; STT3-A |
| NCBI Protein Information: | dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3A |
| UniProt Protein Name: | Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3A |
| UniProt Synonym Protein Names: | B5; Integral membrane protein 1; Transmembrane protein TMC |
| Protein Family: | Dolichyl-diphosphooligosaccharide--protein glycosyltransferase |
| UniProt Gene Name: | STT3A |
| UniProt Entry Name: | STT3A_HUMAN |
| Antibodies |
| STT3A Antibody (PACO12551) |
| Secondary Antibody |
| Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
| Recommended Products |
| Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
| Anti-HRP-conjugated Beta Actin Antibody (CABC028) |
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