STK40 Antibody (PACO15680)
- SKU:
- PACO15680
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Applications:
- IHC
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | STK40 Antibody (PACO15680) |
| Antibody SKU: | PACO15680 |
| Size: | 50ul |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, IHC |
| Recommended Dilutions: | ELISA:1:1000-1:5000, IHC:1:50-1:200 |
| Species Reactivity: | Human, Mouse, Rat |
| Immunogen: | Fusion protein of human STK40 |
| Form: | Liquid |
| Storage Buffer: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
| Purification Method: | Antigen affinity purification |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | The image on the left is immunohistochemistry of paraffin-embedded Human lung cancer tissue using PACO15680(STK40 Antibody) at dilution 1/40, on the right is treated with fusion protein. (Original magnification: x200). |
 | The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using PACO15680(STK40 Antibody) at dilution 1/40, on the right is treated with fusion protein. (Original magnification: x200). |
| Background: | STK40 (Serine/threonine-protein kinase 40), also known as Sugen kinase 495, is a 435 amino acid, protein kinase that may be a negative regulator of NF κ B and p53-mediated gene expression. Localized to both the cytoplasm and the nucleus, STK40 is ubiquitously expressed. STK40 has a central serine/threonine protein kinase domain and is homologous to TRB-3, a protein that regulates activation of MAP kinases and inhibits NF κ B-mediated gene transcription. Similarly, overexpression of STK40 inhibits NF κ B activation triggered by TNF and also inhibits p53-mediated transcription. There are four named isoforms of STK40 that are produced as a result of alternative splicing. |
| Synonyms: | serine/threonine kinase 40 |
| UniProt Protein Function: | SHIK: an ubiquitously expressed protein kinase of the CAMK family. Cytoplasmic. May be a negative regulator of NF-kappaB- and p53-mediated gene transcription.Protein type: EC 2.7.11.1; Protein kinase, CAMK; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); CAMK group; CAMK-Unique familyChromosomal Location of Human Ortholog: 1p34.3Cellular Component: cytoplasm; nucleoplasmMolecular Function: protein binding |
| UniProt Protein Details: | |
| NCBI Summary: | |
| UniProt Code: | Q8N2I9 |
| NCBI GenInfo Identifier: | 116256080 |
| NCBI Gene ID: | 83931 |
| NCBI Accession: | Q8N2I9.2 |
| UniProt Secondary Accession: | Q8N2I9,Q5VTK8, Q5VTK9, Q6ZMN1, Q8N2J8, Q8N3I6, Q96HN6 Q96I44, Q9BSA3, Q9H7H6 |
| UniProt Related Accession: | Q8N2I9 |
| Molecular Weight: | 49,459 Da |
| NCBI Full Name: | Serine/threonine-protein kinase 40 |
| NCBI Synonym Full Names: | serine/threonine kinase 40 |
| NCBI Official Symbol: | STK40 |
| NCBI Official Synonym Symbols: | SHIK; SgK495 |
| NCBI Protein Information: | serine/threonine-protein kinase 40 |
| UniProt Protein Name: | Serine/threonine-protein kinase 40 |
| UniProt Synonym Protein Names: | SINK-homologous serine/threonine-protein kinase; Sugen kinase 495; SgK495 |
| Protein Family: | Serine/threonine-protein kinase |
| UniProt Gene Name: | STK40 |
| UniProt Entry Name: | STK40_HUMAN |
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