STIM1 Polyclonal Antibody
- SKU:
- CAB21614
- Product Type:
- Antibody
- Antibody Type:
- Polyclonal Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- WB
- Applications:
- IHC
- Applications:
- IP
Description
| Product Name: | STIM1 Polyclonal Antibody |
| Product Code: | CAB21614 |
| Reactivity: | Human, Mouse, Rat |
| Applications: | Western blotting, Immunohistochemistry, Immunoprecipitation |
| Host Species: | Rabbit |
| Purification Method: | Affinity purification |
| Isotype: | IgG |
| Reactivity: | Human, Mouse, Rat |
| Tested Applications: | WB, IHC-P, IP, ELISA |
| Key Applications: | Western blotting, Immunohistochemistry, Immunoprecipitation |
| Recommended Dilution: | WB 1:500-1:2000, IHC-P 1:50-1:200, IP 1:500-1:1000 |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal, 50% glycerol, pH7.3. |
| Cellular Location: | Cell membrane, Cytoplasm, Endoplasmic reticulum membrane, Single-pass type I membrane protein, cytoskeleton |
This gene encodes a type 1 transmembrane protein that mediates Ca2+ influx after depletion of intracellular Ca2+ stores by gating of store-operated Ca2+ influx channels (SOCs). It is one of several genes located in the imprinted gene domain of 11p15.5, an important tumor-suppressor gene region. Alterations in this region have been associated with the Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocrotical carcinoma, and lung, ovarian, and breast cancer. This gene may play a role in malignancies and disease that involve this region, as well as early hematopoiesis, by mediating attachment to stromal cells. Mutations in this gene are associated with fatal classic Kaposi sarcoma, immunodeficiency due to defects in store-operated calcium entry (SOCE) in fibroblasts, ectodermal dysplasia and tubular aggregate myopathy. This gene is oriented in a head-to-tail configuration with the ribonucleotide reductase 1 gene (RRM1), with the 3' end of this gene situated 1.6 kb from the 5' end of the RRM1 gene. Alternative splicing of this gene results in multiple transcript variants.
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 451-685 of human STIM1 (NP_003147.2). |
| Sequence: | VAALN IDPSW MGSTR PNPAH FIMTD DVDDM DEEIV SPLSM QSPSL QSSVR QRLTE PQHGL GSQRD LTHSD SESSL HMSDR QRVAP KPPQM SRAAD EALNA MTSNG SHRLI EGVHP GSLVE KLPDS PALAK KALLA LNHGL DKAHS LMELS PSAPP GGSPH LDSSR SHSPS SPDPD TPSPV GDSRA LQASR NTRIP HLAGK KAVAE EDNGS IGEET DSSPG RKKFP LKIFK KPLKK |
| Synonyms: | GOK, TAM, TAM1, IMD10, STRMK, D11S4896E |
| Calculated MW: | 77kDa |
| Observed MW: | Refer to figures |
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