Description
Product Name: | STIM1 Monoclonal Antibody |
Product Code: | CAB22488 |
Reactivity: | Human |
Applications: | Western blotting, Immunohistochemistry, Immunoprecipitation |
Host Species: | Rabbit |
Purification Method: | Affinity purification |
Isotype: | IgG |
Clone No: | ARC57102 |
Reactivity: | Human |
Tested Applications: | WB, IHC-P, IP, ELISA |
Key Applications: | Western blotting, Immunohistochemistry, Immunoprecipitation |
Recommended Dilution: | WB 1:1000-1:5000, IHC-P 1:50-1:200, IP 1:500-1:1000 |
Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300, 0.05% BSA, 50% glycerol, pH7.3. |
Positive Samples: | HeLa, Jurkat, MCF7 |
Cellular Location: | cortical endoplasmic reticulum, endoplasmic reticulum, plasma membrane, plasma membrane raft |
This gene encodes a type 1 transmembrane protein that mediates Ca2+ influx after depletion of intracellular Ca2+ stores by gating of store-operated Ca2+ influx channels (SOCs). It is one of several genes located in the imprinted gene domain of 11p15.5, an important tumor-suppressor gene region. Alterations in this region have been associated with the Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocrotical carcinoma, and lung, ovarian, and breast cancer. This gene may play a role in malignancies and disease that involve this region, as well as early hematopoiesis, by mediating attachment to stromal cells. Mutations in this gene are associated with fatal classic Kaposi sarcoma, immunodeficiency due to defects in store-operated calcium entry (SOCE) in fibroblasts, ectodermal dysplasia and tubular aggregate myopathy. This gene is oriented in a head-to-tail configuration with the ribonucleotide reductase 1 gene (RRM1), with the 3' end of this gene situated 1.6 kb from the 5' end of the RRM1 gene. Alternative splicing of this gene results in multiple transcript variants.
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 530-685 of human STIM1 (NP_003147.2). |
Sequence: | RQRVA PKPPQ MSRAA DEALN AMTSN GSHRL IEGVH PGSLV EKLPD SPALA KKALL ALNHG LDKAH SLMEL SPSAP PGGSP HLDSS RSHSP SSPDP DTPSP VGDSR ALQAS RNTRI PHLAG KKAVA EEDNG SIGEE TDSSP GRKKF PLKIF KKPLK K |
Synonyms: | GOK, TAM, TAM1, IMD10, STRMK, D11S4896E |
Calculated MW: | 77kDa |
Observed MW: | Refer to figures |