Name: STEAP2 Antibody (PACO23268)
SKU: PACO23268
Availability: OutOfStock

Antibody Name:	STEAP2 Antibody (PACO23268)
Antibody SKU:	PACO23268
Size:	100ul
Host Species:	Rabbit
Tested Applications:	ELISA, IHC, IF
Recommended Dilutions:	ELISA:1:2000-1:10000, IHC:1:50-1:100, IF:1:100-1:500
Species Reactivity:	Human, Mouse
Immunogen:	Synthesized peptide derived from C-terminal of human STEA2.

Form:	Liquid
Storage Buffer:	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Purification Method:	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Clonality:	Polyclonal
Isotype:	IgG
Conjugate:	Non-conjugated

	Immunohistochemistry analysis of paraffin-embedded human colon carcinoma tissue, using STEA2 antibody.
	Immunofluorescence analysis of A549 cells, using STEA2 antibody.

Background:	Metalloreductase that has the ability to reduce both Fe3+ to Fe2+ and Cu2+ to Cu1+. Uses NAD+ as acceptor By similarity.
Synonyms:	EC 1.16.1.-; Six-transmembrane epithelial antigen of prostate 2; SixTransMembrane protein of prostate 1; Prostate cancer-associated protein 1;

UniProt Protein Function:	STEAP2: Metalloreductase that has the ability to reduce both Fe(3+) to Fe(2+) and Cu(2+) to Cu(1+). Uses NAD(+) as acceptor. Belongs to the STEAP family. 2 isoforms of the human protein are produced by alternative splicing.Protein type: Oxidoreductase; EC 1.16.1.-; Membrane protein, integral; Vesicle; Membrane protein, multi-passChromosomal Location of Human Ortholog: 7q21.13Cellular Component: trans-Golgi network transport vesicle; intracellular membrane-bound organelle; early endosome; plasma membrane; integral to Golgi membrane; endosome membrane; cytosolMolecular Function: transporter activity; metal ion binding; cupric reductase activityBiological Process: regulated secretory pathway; Golgi to plasma membrane transport; iron ion homeostasis; response to hormone stimulus; copper ion import; endocytosis
UniProt Protein Details:
NCBI Summary:	This gene is a member of the STEAP family and encodes a multi-pass membrane protein that localizes to the Golgi complex, the plasma membrane, and the vesicular tubular structures in the cytosol. A highly similar protein in mouse has both ferrireductase and cupric reductase activity, and stimulates the cellular uptake of both iron and copper in vitro. Increased transcriptional expression of the human gene is associated with prostate cancer progression. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]
UniProt Code:	Q8NFT2
NCBI GenInfo Identifier:	100913198
NCBI Gene ID:	261729
NCBI Accession:	NP_001035756.1
UniProt Secondary Accession:	Q8NFT2,Q6UXN6, Q6YPB1, Q8IUE7, A4D1F1, G5E9C6
UniProt Related Accession:	Q8NFT2
Molecular Weight:	47,916 Da
NCBI Full Name:	metalloreductase STEAP2 isoform b
NCBI Synonym Full Names:	STEAP2 metalloreductase
NCBI Official Symbol:	STEAP2
NCBI Official Synonym Symbols:	STMP; IPCA1; PUMPCn; STAMP1; PCANAP1
NCBI Protein Information:	metalloreductase STEAP2
UniProt Protein Name:	Metalloreductase STEAP2
UniProt Synonym Protein Names:	Prostate cancer-associated protein 1; Protein up-regulated in metastatic prostate cancer; PUMPCn; Six-transmembrane epithelial antigen of prostate 2; SixTransMembrane protein of prostate 1
Protein Family:
UniProt Gene Name:	STEAP2
UniProt Entry Name:	STEA2_HUMAN